Vilsvik J S, Schaanning J
Br Med J. 1976 Aug 21;2(6033):453-5. doi: 10.1136/bmj.2.6033.453.
The effects on ventilatory and cardiac function of atenolol, a new cardioselective beta-adrenoceptor blocking agent, were compared with those of practolol in a double-blind trial in 12 patients with asthma. Both drugs impaired ventilatory function--atenolol insignificantly and practolol significantly. Atenolol was if anything more cardioselective than practolol. Neither drug interfered significantly with the bronchodilator response to inhaled isoprenaline. Atenolol is suitable for use in patients for whom practolol would formerly have been chosen because of its cardioselectivity.
在一项针对12名哮喘患者的双盲试验中，将新型心脏选择性β-肾上腺素受体阻滞剂阿替洛尔对通气和心脏功能的影响与心得宁进行了比较。两种药物均损害通气功能——阿替洛尔的损害不显著，心得宁的损害显著。实际上，阿替洛尔比心得宁更具心脏选择性。两种药物对吸入异丙肾上腺素的支气管扩张反应均无显著干扰。由于其心脏选择性，阿替洛尔适用于以前会选用心得宁的患者。
