Pollack Anna Z, Mumford Sunni L, Sjaarda Lindsey, Perkins Neil J, Malik Farah, Wactawski-Wende Jean, Schisterman Enrique F
Department of Global and Community Health, College of Health and Human Services, George Mason University, 4400 University Drive MS5B7, Fairfax, VA, 22030, USA.
Epidemiology Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA.
Environ Health. 2017 Aug 8;16(1):84. doi: 10.1186/s12940-017-0293-6.
To examine the relationship between cadmium, lead, and mercury concentrations with high-sensitivity C-reactive protein (hs-CRP) and homocysteine in women.
Metals were measured at enrollment in whole blood. Homocysteine and hs-CRP were measured in one (N = 9) or two (N = 250) menstrual cycles up to 3 and 8 times per cycle, respectively. Linear mixed models with inverse probability of exposure weights to account for time varying confounding were used and models were stratified by dietary and serum vitamin status (dietary: vitamin B, B, folate; serum: folate).
Geometric mean (95% confidence interval (CI)) concentrations for cadmium, lead, and mercury were 0.29 (0.26-0.31) μg/L, 0.91 (0.86-0.96) μg/dL, and 1.05 (0.93-1.18) μg/L, respectively. Lead was associated with increased homocysteine (0.08; 95% CI: 0.01, 0.15) and this persisted among those in the lower three quartiles of consumption of vitamin B, B, folate, and serum folate but was not significant among those in the upper quartile. No associations were observed between metals and hs-CRP.
Blood lead was associated with increased homocysteine in a cohort of healthy, premenopausal women but these associations did not persist among those consuming ≥75th percentile of essential micronutrients. Cadmium, lead, and mercury were not associated with hs-CRP concentrations.
研究女性体内镉、铅和汞浓度与高敏C反应蛋白（hs-CRP）及同型半胱氨酸之间的关系。
入组时测量全血中的金属含量。在一个（N = 9）或两个（N = 250）月经周期内测量同型半胱氨酸和hs-CRP，每个周期分别测量3次和8次。使用具有暴露权重逆概率的线性混合模型来解释随时间变化的混杂因素，并按饮食和血清维生素状态（饮食：维生素B、B、叶酸；血清：叶酸）对模型进行分层。
镉、铅和汞的几何平均（95%置信区间（CI））浓度分别为0.29（0.26 - 0.31）μg/L、0.91（0.86 - 0.96）μg/dL和1.05（0.93 - 1.18）μg/L。铅与同型半胱氨酸升高相关（0.08；95%CI：0.01，0.15），在维生素B、B、叶酸和血清叶酸摄入量处于较低三个四分位数的人群中这种相关性持续存在，但在四分位数较高的人群中不显著。未观察到金属与hs-CRP之间存在关联。
在一组健康的绝经前女性中，血铅与同型半胱氨酸升高相关，但在摄入必需微量营养素≥第75百分位数的人群中，这些关联并不持续存在。镉、铅和汞与hs-CRP浓度无关。
