Wang Bo-Kai, Chen Wei-Liang
Department of Anesthesiology, Tri-Service General Hospital, School of Medicine, National Defense Medical Center, Taipei, Taiwan, ROC.
Department of Internal Medicine, Tri-Service General Hospital, School of Medicine, National Defense Medical Center, Taipei, Taiwan, ROC.
Sci Rep. 2022 Apr 22;12(1):6628. doi: 10.1038/s41598-022-10562-9.
Increasing studies have demonstrated the association between heavy metal pollution and micronutrients, especially folate. However, the relationship between cadmium and folate remains rarely discussed. In this study, we aim to explore the potential correlation between cadmium and folate in human population and highlight the possible mechanism of cadmium impacting human health. We utilized the National Health and Nutrition Examination Survey (NHANES) 2017-2018 data with 5690 participants in this study. Multivariable linear regression models were adopted to investigate the serum lead and cadmium levels and RBC folate concentration. A significant reverse relationship was found between serum lead and cadmium and RBC folate. A negative relationship between serum lead and cadmium levels and the levels of RBC folate in the U.S. adult population was found in this study. Nevertheless, due to the general limitations of the NHANES data, as a cross-sectional study, a further prospective investigation is needed to discover the causality of lead and cadmium in folate status and to determine whether the folate supplement has a beneficial influence against heavy metal toxicities.
越来越多的研究表明重金属污染与微量营养素之间存在关联，尤其是叶酸。然而，镉与叶酸之间的关系仍很少被讨论。在本研究中，我们旨在探讨人群中镉与叶酸之间的潜在相关性，并突出镉影响人类健康的可能机制。我们使用了2017 - 2018年美国国家健康与营养检查调查（NHANES）的数据，本研究中有5690名参与者。采用多变量线性回归模型来研究血清铅和镉水平以及红细胞叶酸浓度。发现血清铅和镉与红细胞叶酸之间存在显著的负相关关系。本研究发现美国成年人群中血清铅和镉水平与红细胞叶酸水平之间存在负相关关系。然而，由于NHANES数据的一般局限性，作为一项横断面研究，需要进一步进行前瞻性调查，以发现铅和镉在叶酸状态中的因果关系，并确定叶酸补充剂是否对重金属毒性具有有益影响。
