PREDAPS研究中一般肥胖和腹型肥胖与高血压、血脂异常及糖尿病前期的关联

Association of General and Abdominal Obesity With Hypertension, Dyslipidemia and Prediabetes in the PREDAPS Study.

作者信息

Sangrós F Javier, Torrecilla Jesús, Giráldez-García Carolina, Carrillo Lourdes, Mancera José, Mur Teresa, Franch Josep, Díez Javier, Goday Albert, Serrano Rosario, García-Soidán F Javier, Cuatrecasas Gabriel, Igual Dimas, Moreno Ana, Millaruelo J Manuel, Carramiñana Francisco, Ruiz Manuel Antonio, Pérez Francisco Carlos, Iriarte Yon, Lorenzo Ángela, González María, Álvarez Beatriz, Barutell Lourdes, Mayayo M Soledad, Del Castillo Mercedes, Navarro Emma, Malo Fernando, Cambra Ainhoa, López Riánsares, Gutiérrez M Ángel, Gutiérrez Luisa, Boente Carmen, Mediavilla J Javier, Prieto Luis, Mendo Luis, Mansilla M José, Ortega Francisco Javier, Borras Antonia, Sánchez L Gabriel, Obaya J Carlos, Alonso Margarita, García Francisco, Gutiérrez Ángela Trinidad, Hernández Ana M, Suárez Dulce, Álvarez J Carlos, Sáenz Isabel, Martínez F Javier, Casorrán Ana, Ripoll Jazmín, Salanova Alejandro, Marín M Teresa, Gutiérrez Félix, Innerárity Jaime, Álvarez M Del Mar, Artola Sara, Bedoya M Jesús, Poveda Santiago, Álvarez Fernando, Brito M Jesús, Iglesias Rosario, Paniagua Francisca, Nogales Pedro, Gómez Ángel, Rubio José Félix, Durán M Carmen, Sagredo Julio, Gijón M Teresa, Rollán M Ángeles, Pérez Pedro P, Gamarra Javier, Carbonell Francisco, García-Giralda Luis, Antón J Joaquín, de la Flor Manuel, Martínez Rosario, Pardo José Luis, Ruiz Antonio, Plana Raquel, Macía Ramón, Villaró Mercè, Babace Carmen, Torres José Luis, Blanco Concepción, Jurado Ángeles, Martín José Luis, Navarro Jorge, Sanz Gloria, Colas Rafael, Cordero Blanca, de Castro Cristina, Ibáñez Mercedes, Monzón Alicia, Porta Nuria, Gómez María Del Carmen, Llanes Rafael, Rodríguez J José, Granero Esteban, Sánchez Manuel, Martínez Juan, Ezkurra Patxi, Ávila Luis, de la Sen Carlos, Rodríguez Antonio, Buil Pilar, Gabriel Paula, Roura Pilar, Tarragó Eduard, Mundet Xavier, Bosch Remei, González J Carles, Bobé M Isabel, Mata Manel, Ruiz Irene, López Flora, Birules Marti, Armengol Oriol, de Miguel Rosa Mar, Romera Laura, Benito Belén, Piulats Neus, Bilbeny Beatriz, Cabré J José, Cos Xavier, Pujol Ramón, Seguí Mateu, Losada Carmen, de Santiago A María, Muñoz Pedro, Regidor Enrique

机构信息

Atención Primaria, Centro de Salud Torrero-La Paz, Zaragoza, Spain.

Atención Primaria, Centro de Salud Bombarda-Monsalud, Zaragoza, Spain.

出版信息

Rev Esp Cardiol (Engl Ed). 2018 Mar;71(3):170-177. doi: 10.1016/j.rec.2017.04.035. Epub 2017 Aug 5.

DOI:10.1016/j.rec.2017.04.035

PMID:28789915

Abstract

INTRODUCTION AND OBJECTIVES

Some anthropometric measurements show a greater capacity than others to identify the presence of cardiovascular risk factors. This study estimated the magnitude of the association of different anthropometric indicators of obesity with hypertension, dyslipidemia, and prediabetes (altered fasting plasma glucose and/or glycosylated hemoglobin).

METHODS

Cross-sectional analysis of information collected from 2022 participants in the PREDAPS study (baseline phase). General obesity was defined as body mass index ≥ 30kg/m and abdominal obesity was defined with 2 criteria: a) waist circumference (WC) ≥ 102cm in men/WC ≥ 88cm in women, and b) waist-height ratio (WHtR) ≥ 0.55. The magnitude of the association was estimated by logistic regression.

RESULTS

Hypertension showed the strongest association with general obesity in women (OR, 3.01; 95%CI, 2.24-4.04) and with abdominal obesity based on the WHtR criterion in men (OR, 3.65; 95%CI, 2.66-5.01). Hypertriglyceridemia and low levels of high-density lipoprotein cholesterol showed the strongest association with abdominal obesity based on the WHtR criterion in women (OR, 2.49; 95%CI, 1.68-3.67 and OR, 2.70; 95%CI, 1.89-3.86) and with general obesity in men (OR, 2.06; 95%CI, 1.56-2.73 and OR, 1.68; 95%CI, 1.21-2.33). Prediabetes showed the strongest association with abdominal obesity based on the WHtR criterion in women (OR, 2.48; 95%CI, 1.85-3.33) and with abdominal obesity based on the WC criterion in men (OR, 2.33; 95%CI, 1.75-3.08).

CONCLUSIONS

Abdominal obesity indicators showed the strongest association with the presence of prediabetes. The association of anthropometric indicators with hypertension and dyslipidemia showed heterogeneous results.

摘要

引言与目的

一些人体测量指标在识别心血管危险因素方面比其他指标具有更强的能力。本研究估计了不同肥胖人体测量指标与高血压、血脂异常和糖尿病前期（空腹血糖和/或糖化血红蛋白改变）之间关联的强度。

方法

对PREDAPS研究（基线期）的2022名参与者收集的信息进行横断面分析。一般肥胖定义为体重指数≥30kg/m²，腹型肥胖用两个标准定义：a）男性腰围（WC）≥102cm/女性WC≥88cm，b）腰高比（WHtR）≥0.55。通过逻辑回归估计关联强度。

结果

高血压在女性中与一般肥胖的关联最强（比值比[OR]，3.01；95%置信区间[CI]，2.24 - 4.04），在男性中与基于腰高比标准的腹型肥胖关联最强（OR，3.65；95%CI，2.66 - 5.01）。高甘油三酯血症和低水平高密度脂蛋白胆固醇在女性中与基于腰高比标准的腹型肥胖关联最强（OR，2.49；95%CI，1.68 - 3.67和OR，2.70；95%CI，1.89 - 3.86），在男性中与一般肥胖关联最强（OR，2.06；95%CI，1.56 - 2.73和OR，1.68；95%CI，1.21 - 2.33）。糖尿病前期在女性中与基于腰高比标准的腹型肥胖关联最强（OR，2.48；95%CI，1.85 - 3.33），在男性中与基于腰围标准的腹型肥胖关联最强（OR，2.33；95%CI，

1.75 - 3.08）。