Wang Chin-An, Blohm Gunnar, Huang Jeff, Boehnke Susan E, Munoz Douglas P
Centre for Neuroscience Studies, Queen's University, Kingston, Ontario, Canada.
Centre for Neuroscience Studies, Queen's University, Kingston, Ontario, Canada.
Biol Psychol. 2017 Oct;129:36-44. doi: 10.1016/j.biopsycho.2017.07.024. Epub 2017 Aug 5.
Signals from different sensory modalities are integrated in the brain to optimize behavior. Although multisensory integration has been demonstrated in saccadic eye movements, its influence on other orienting responses, including pupil size and microsaccades, is still poorly understood. We examined human gaze orienting responses following presentation of visual, auditory, or combined audiovisual stimuli. Transient pupil dilation and microsaccade inhibition were evoked shortly after the appearance of a salient stimulus. Audiovisual stimuli evoked larger pupil dilation, greater microsaccade inhibition, and faster saccade reaction times compared to unimodal conditions. Trials with faster saccadic reaction times were accompanied with greater pupil dilation responses. Similar modulation of pre-stimulus pupil-size-change rate was observed between stimulus-evoked saccadic and pupillary responses. Thus, multisensory integration impacts multiple components of orienting, with coordination between saccade and pupil responses, implicating the superior colliculus in coordinating these responses because of its central role in both orienting behavior and multisensory integration.
来自不同感觉模态的信号在大脑中整合以优化行为。尽管在眼球快速运动中已证明存在多感觉整合，但其对包括瞳孔大小和微扫视在内的其他定向反应的影响仍知之甚少。我们研究了在呈现视觉、听觉或视听组合刺激后人类的注视定向反应。在显著刺激出现后不久，会诱发短暂的瞳孔扩张和微扫视抑制。与单模态条件相比，视听刺激诱发更大的瞳孔扩张、更强的微扫视抑制和更快的扫视反应时间。扫视反应时间更快的试验伴随着更大的瞳孔扩张反应。在刺激诱发的扫视和瞳孔反应之间观察到刺激前瞳孔大小变化率的类似调制。因此，多感觉整合影响定向的多个组成部分，扫视和瞳孔反应之间存在协调，这意味着上丘在协调这些反应中发挥作用，因为它在定向行为和多感觉整合中都起着核心作用。
