Centre for Chronobiology, Psychiatric Hospital of the University of Basel, 4012, Basel, Switzerland.
Transfaculty Research Platform Molecular and Cognitive Neurosciences, University of Basel, Basel, Switzerland.
Sci Rep. 2017 Aug 8;7(1):7620. doi: 10.1038/s41598-017-07060-8.
We tested the effect of different lights as a countermeasure against sleep-loss decrements in alertness, melatonin and cortisol profile, skin temperature and wrist motor activity in healthy young and older volunteers under extendend wakefulness. 26 young [mean (SE): 25.0 (0.6) y)] and 12 older participants [(mean (SE): 63.6 (1.3) y)] underwent 40-h of sustained wakefulness during 3 balanced crossover segments, once under dim light (DL: 8 lx), and once under either white light (WL: 250 lx, 2,800 K) or blue-enriched white light (BL: 250 lx, 9,000 K) exposure. Subjective sleepiness, melatonin and cortisol were assessed hourly. Skin temperature and wrist motor activity were continuously recorded. WL and BL induced an alerting response in both the older (p = 0.005) and the young participants (p = 0.021). The evening rise in melatonin was attentuated under both WL and BL only in the young. Cortisol levels were increased and activity levels decreased in the older compared to the young only under BL (p = 0.0003). Compared to the young, both proximal and distal skin temperatures were lower in older participants under all lighting conditions. Thus the color temperature of normal intensity lighting may have differential effects on circadian physiology in young and older individuals.
我们测试了不同光线作为对抗睡眠剥夺对警觉性、褪黑素和皮质醇谱、皮肤温度和手腕运动活动影响的对策，在延长清醒状态下，健康的年轻和老年志愿者。26 名年轻志愿者[平均（SE）：25.0（0.6）y)]和 12 名老年志愿者[平均（SE）：63.6（1.3）y)]在 3 个平衡交叉段中进行了 40 小时的持续清醒，一次在暗光（DL：8 lx）下，一次在白光（WL：250 lx，2800 K）或蓝光增强白光（BL：250 lx，9000 K）下。每小时评估主观困倦、褪黑素和皮质醇。连续记录皮肤温度和手腕运动活动。WL 和 BL 在年轻和老年参与者中都引起了警觉反应（p=0.005 和 p=0.021）。只有在年轻志愿者中，在 WL 和 BL 下，褪黑素的傍晚升高被减弱。与年轻志愿者相比，只有在 BL 下，皮质醇水平升高，活动水平降低（p=0.0003）。与年轻志愿者相比，在所有光照条件下，老年志愿者的近端和远端皮肤温度都较低。因此，正常强度光照的色温可能对年轻和老年个体的生物钟生理学产生不同的影响。
