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ICS/LABA 联合用药在人群中的使用率与哮喘结局的改善是否相关?新西兰和澳大利亚全国代表性人群的横断面调查。

Is higher population-level use of ICS/LABA combination associated with better asthma outcomes? Cross-sectional surveys of nationally representative populations in New Zealand and Australia.

机构信息

Woolcock Institute of Medical Research, University of Sydney, Glebe, NSW, Australia.

Department of Medicine, University of Otago, Christchurch, New Zealand.

出版信息

Respirology. 2017 Nov;22(8):1570-1578. doi: 10.1111/resp.13123. Epub 2017 Aug 9.

DOI:10.1111/resp.13123
PMID:28791752
Abstract

BACKGROUND AND OBJECTIVE

New Zealand (NZ) and Australia (AU) have similarly high asthma prevalence; both have universal public health systems, but different criteria for subsidized medicines. We explored differences in asthma management and asthma-related outcomes between these countries.

METHODS

A web-based survey was administered in AU (2012) and NZ (2013) to individuals aged ≥16 years with current asthma, drawn randomly from web-based panels, stratified by national population proportions. Symptom control was assessed with the Asthma Control Test (ACT). Healthcare utilization was assessed from reported urgent doctor/hospital visits in the previous year.

RESULTS

NZ (n = 537) and Australian (n = 2686) participants had similar age and gender distribution. More NZ than Australian participants used inhaled corticosteroid (ICS)-containing medication (68.8% vs 60.9%; P = 0.006) but ICS/long-acting β -agonist (LABA) constituted 44.4% of NZ and 81.5% of Australian total ICS use (P < 0.0001). Adherence was higher with ICS/LABA than ICS-alone (P < 0.0001), and higher in NZ than in AU (P < 0.0001). ACT scores were similar (P = 0.41), with symptoms well controlled in 58.6% and 54.4% participants, respectively. More NZ participants reported non-urgent asthma reviews (56.6% vs 50.4%; P = 0.009). Similar proportions had urgent asthma visits (27.9% and 28.6%, respectively, P = 0.75).

CONCLUSION

This comparison, which included the first nationally representative data for asthma control in NZ, showed that poorly controlled asthma is common in both NZ and AU, despite subsidized ICS-containing medications. The greater use of ICS-alone in NZ relative to ICS/LABA does not appear to have compromised population-level asthma outcomes, perhaps due to better adherence in NZ. Different ICS/LABA subsidy criteria and different patient copayments may also have contributed to these findings.

摘要

背景与目的

新西兰(NZ)和澳大利亚(AU)的哮喘患病率相似;两国均拥有全民公共卫生系统,但补贴药物的标准不同。我们旨在探讨这两个国家之间哮喘管理和哮喘相关结局的差异。

方法

我们于 2012 年在澳大利亚和 2013 年在新西兰开展了一项基于网络的调查,对象为当前患有哮喘且年龄≥16 岁的个体,他们是从基于网络的小组中随机抽取的,按全国人口比例分层。采用哮喘控制测试(ACT)评估症状控制情况。根据上一年报告的紧急看医生/住院就诊情况评估医疗保健的使用情况。

结果

NZ(n=537)和澳大利亚(n=2686)参与者的年龄和性别分布相似。与澳大利亚参与者相比,更多的 NZ 参与者使用含有吸入性皮质类固醇(ICS)的药物(68.8% vs 60.9%;P=0.006),但 ICS/长效β-激动剂(LABA)构成了 NZ 参与者(44.4%)和澳大利亚参与者(81.5%)ICS 总使用量的一部分(P<0.0001)。ICS/LABA 的依从性高于 ICS 单药(P<0.0001),且 NZ 参与者的依从性高于澳大利亚参与者(P<0.0001)。ACT 评分相似(P=0.41),分别有 58.6%和 54.4%的参与者症状得到良好控制。更多的 NZ 参与者报告进行了非紧急性哮喘复查(56.6% vs 50.4%;P=0.009)。有紧急哮喘就诊的参与者比例相似(分别为 27.9%和 28.6%,P=0.75)。

结论

本研究纳入了 NZ 全国范围内首次具有代表性的哮喘控制数据,结果表明,尽管使用了补贴的 ICS 药物,但 NZ 和 AU 两国的哮喘控制不良仍很常见。与 ICS/LABA 相比,NZ 中更广泛地使用 ICS 单药似乎并未影响人群层面的哮喘结局,这可能归因于 NZ 中更高的依从性。不同的 ICS/LABA 补贴标准和不同的患者共付额也可能促成了这些发现。

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