用于氨肽酶N体内成像的近红外荧光探针的设计、合成与应用
Design, synthesis and application of a near-infrared fluorescent probe for in vivo imaging of aminopeptidase N.
作者信息
He Xinyuan, Hu Yiming, Shi Wen, Li Xiaohua, Ma Huimin
机构信息
Beijing National Laboratory for Molecular Sciences, Key Laboratory of Analytical Chemistry for Living Biosystems, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China.
出版信息
Chem Commun (Camb). 2017 Aug 22;53(68):9438-9441. doi: 10.1039/c7cc05142e.
We have, for the first time, developed a near-infrared fluorescent probe for aminopeptidase N by combining a hemicyanine and an alanyl residue. The probe exhibits high selectivity and sensitivity with a detection limit of 0.8 ng mL. With the probe, aminopeptidase N has been imaged in both cells and mice in vivo, indicating a promising tool for studying the function of the enzyme.
我们首次通过将半菁和丙氨酰残基结合，开发出了一种用于氨肽酶N的近红外荧光探针。该探针具有高选择性和高灵敏度，检测限为0.8 ng/mL。利用该探针，已在体内对细胞和小鼠中的氨肽酶N进行了成像，表明它是研究该酶功能的一种有前景的工具。
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