Ignatov Dmitriy, Johansson Jörgen
Umeå Centre for Microbial Research, Umeå University, Umeå, Sweden.
Department of Molecular Biology, Umeå University, Umeå, Sweden.
Wiley Interdiscip Rev RNA. 2017 Nov;8(6). doi: 10.1002/wrna.1429. Epub 2017 Aug 9.
Bacterial pathogens encounter several different environments during an infection, many of them possibly being detrimental. In order to sense its surroundings and adjust the gene expression accordingly, different regulatory schemes are undertaken. With these, the bacterium appropriately can differentiate between various environmental cues to express the correct virulence factor at the appropriate time and place. An attractive regulator device is RNA, which has an outstanding ability to alter its structure in response to external stimuli, such as metabolite concentration or alterations in temperature, to control its downstream gene expression. This review will describe the function of riboswitches and thermometers, with a particular emphasis on regulatory RNAs being important for bacterial pathogenicity. WIREs RNA 2017, 8:e1429. doi: 10.1002/wrna.1429 For further resources related to this article, please visit the WIREs website.
细菌病原体在感染过程中会遇到几种不同的环境，其中许多可能是有害的。为了感知周围环境并相应地调整基因表达，细菌会采用不同的调控机制。通过这些机制，细菌能够适当地区分各种环境信号，以便在合适的时间和地点表达正确的毒力因子。一种引人注目的调控装置是RNA，它具有出色的能力，能够响应外部刺激（如代谢物浓度或温度变化）改变其结构，从而控制其下游基因表达。本综述将描述核糖开关和温度计的功能，特别强调对细菌致病性很重要的调控RNA。WIREs RNA 2017, 8:e1429. doi: 10.1002/wrna.1429 有关本文的更多资源，请访问WIREs网站。
