Pummer Andreas, Knüttel Helge, Hiller Karl-Anton, Buchalla Wolfgang, Cieplik Fabian, Maisch Tim
Department of Conservative Dentistry & Periodontology, University Medical Center Regensburg, 93053 Regensburg, Germany.
University Library, University of Regensburg, 93053 Regensburg, Germany.
Future Med Chem. 2017 Sep;9(13):1557-1574. doi: 10.4155/fmc-2017-0051. Epub 2017 Aug 9.
Resistances to antibiotics employed for treatment of infectious diseases have increased to alarming numbers making it more and more difficult to treat diseases caused by microorganisms resistant to common antibiotics. Consequently, novel methods for successful inactivation of pathogens are required. In this instance, one alternative could be application of light for treatment of topical infections. Antimicrobial properties of UV light are well documented, but due to its DNA-damaging properties use for medical purposes is limited. In contrast, irradiation with visible light may be more promising.
Literature was systematically screened for research concerning inactivation of main oral bacterial species by means of visible light.
Inactivation of bacterial species, especially pigmented ones, in planktonic state showed promising results. There is a lack of research examining the situation when organized as biofilms.
More research concerning situation in a biofilm state is required.
用于治疗传染病的抗生素耐药性已上升到惊人的数量，使得治疗由对常用抗生素耐药的微生物引起的疾病变得越来越困难。因此，需要新的成功灭活病原体的方法。在这种情况下，一种替代方法可能是用光治疗局部感染。紫外线的抗菌特性已有充分记录，但由于其对DNA的损伤特性，其在医学上的应用受到限制。相比之下，可见光照射可能更有前景。
系统筛选有关通过可见光灭活主要口腔细菌种类的研究文献。
浮游状态下细菌种类的灭活，尤其是有色细菌，显示出有前景的结果。缺乏对生物膜状态下情况的研究。
需要更多关于生物膜状态下情况的研究。
