Shiro Yukiko, Arai Young-Chang, Ikemoto Tatsunori, Hayashi Kazuhiro
Department of Physical Therapy, Faculty of Rehabilitation Sciences, Nagoya Gakuin University, Nagoya, Japan.
Multidisciplinary Pain Center, Aichi Medical University, Nagakute, Japan.
PLoS One. 2017 Aug 9;12(8):e0182859. doi: 10.1371/journal.pone.0182859. eCollection 2017.
Commensal as well as pathogenic bacteria can influence a variety of gut functions, thereby leading to constipation and diarrhea in severe cases. In fact, several researchers have reported evidence supporting the association between stool consistency or constipation and the Gut microbiome (GM) composition and dysbiosis. GM influences the human health and disease via the gut-brain axis. We thus hypothesized that the pathogenic bacteria increases pain perception to some extent, which means that there could be an association between stool consistency or constipation and pain perception of healthy subjects.
Observational study.
The aim of the present study was to investigate the association between stool consistency or constipation and pain perception of healthy subjects.
Thirty-eight healthy subjects participated in this study. The participants were assessed on their usual stool form (the Bristol Stool Form Scale: BSFS), constipation (the Cleveland Clinic Constipation score: CCS), degree of obesity, pain perception by mechanical stimulus, cold pain threshold, and a questionnaire on psychological state.
The BSFS was significantly and positively associated with pain perception, and showed a significant association with anxiety states. Furthermore, pain perception was significantly associated with anxiety states. However, there were no significant associations between the CCS and any independent variables. In addition, we found that a significant predictor to the pain perception was BSFS. Moreover, there were significant relationships among the psychological states, BSFS and obesity.
These results suggest that the stool form is associated with pain perception and anxiety status.
共生菌和致病菌均可影响多种肠道功能，严重时可导致便秘和腹泻。事实上，已有多位研究人员报告了支持粪便稠度或便秘与肠道微生物群（GM）组成及失调之间关联的证据。GM通过肠-脑轴影响人类健康和疾病。因此，我们推测致病菌在一定程度上会增加疼痛感知，这意味着粪便稠度或便秘与健康受试者的疼痛感知之间可能存在关联。
观察性研究。
本研究旨在调查粪便稠度或便秘与健康受试者疼痛感知之间的关联。
38名健康受试者参与了本研究。对参与者的日常粪便形态（布里斯托粪便形态量表：BSFS）、便秘情况（克利夫兰诊所便秘评分：CCS）、肥胖程度、机械刺激疼痛感知、冷痛阈值以及心理状态问卷进行了评估。
BSFS与疼痛感知显著正相关，且与焦虑状态显著相关。此外，疼痛感知与焦虑状态显著相关。然而，CCS与任何自变量之间均无显著关联。此外，我们发现疼痛感知的一个显著预测因素是BSFS。此外，心理状态、BSFS和肥胖之间存在显著关系。
这些结果表明粪便形态与疼痛感知和焦虑状态有关。
