Sheikh Zeeshan, Abdallah Mohamed-Nur, Hanafi Ahmed Abdalla, Misbahuddin Syed, Rashid Haroon, Glogauer Michael
Faculty of Dentistry, University of Toronto, Toronto, ON M5S 3E2, Canada.
Faculty of Dentistry, McGill University, Montreal, QC H3A 1G1, Canada.
Materials (Basel). 2015 Nov 23;8(11):7913-7925. doi: 10.3390/ma8115430.
Calcium phosphate ceramic materials are extensively used for bone replacement and regeneration in orthopedic, dental, and maxillofacial surgical applications. In order for these biomaterials to work effectively it is imperative that they undergo the process of degradation and resorption . This allows for the space to be created for the new bone tissue to form and infiltrate within the implanted graft material. Several factors affect the biodegradation and resorption of calcium phosphate materials after implantation. Various cell types are involved in the degradation process by phagocytic mechanisms (monocytes/macrophages, fibroblasts, osteoblasts) or via an acidic mechanism to reduce the micro-environmental pH which results in demineralization of the cement matrix and resorption via osteoclasts. These cells exert their degradation effects directly or indirectly through the cytokine growth factor secretion and their sensitivity and response to these biomolecules. This article discusses the mechanisms of calcium phosphate material degradation .
磷酸钙陶瓷材料广泛应用于骨科、牙科和颌面外科手术中的骨替代和再生。为了使这些生物材料有效发挥作用，它们必须经历降解和吸收过程。这为新骨组织在植入的移植材料内形成和浸润创造了空间。植入后，有几个因素会影响磷酸钙材料的生物降解和吸收。多种细胞类型通过吞噬机制（单核细胞/巨噬细胞、成纤维细胞、成骨细胞）或通过酸性机制参与降解过程，酸性机制会降低微环境pH值，导致骨水泥基质脱矿并通过破骨细胞进行吸收。这些细胞通过细胞因子生长因子的分泌以及它们对这些生物分子的敏感性和反应直接或间接地发挥降解作用。本文讨论了磷酸钙材料的降解机制。
