Buchanan K D, Johnston C F, O'Hare M M, Ardill J E, Shaw C, Collins J S, Watson R G, Atkinson A B, Hadden D R, Kennedy T L
Am J Med. 1986 Dec 22;81(6B):14-22. doi: 10.1016/0002-9343(86)90581-4.
A center in Belfast, Northern Ireland, has established a register for tumors of the gastroenteropancreatic endocrine system. Carcinoid tumors occur most frequently. Of the non-carcinoid tumors, insulinomas, gastrinomas, and unknown types have the highest incidence, with other types being extremely rare. The potentially remediable nature of the tumors is stressed, and frequently a good quality of life can be experienced even in the presence of metastatic disease. The syndromes are probably underdiagnosed as they present with clinical features for which there are more common explanations, and appropriate diagnostic methods are therefore not used. The management of the syndromes is reviewed with particular emphasis on the treatment of patients with inoperable disease. Histamine (H2)-receptor antagonist therapy has made an impact in Zollinger-Ellison syndrome, and streptozotocin and somatostatin analogues can control tumor growth and endocrine syndromes, respectively.
北爱尔兰贝尔法斯特的一个中心已建立了胃肠胰内分泌系统肿瘤登记册。类癌肿瘤最为常见。在非类癌肿瘤中，胰岛素瘤、胃泌素瘤和不明类型的发病率最高，其他类型极为罕见。强调了肿瘤潜在的可治愈性，即使存在转移性疾病，患者通常也能有较好的生活质量。这些综合征可能诊断不足，因为它们表现出的临床特征有更常见的解释，因此未采用适当的诊断方法。对这些综合征的管理进行了综述，特别强调了对无法手术治疗的患者的治疗。组胺（H2）受体拮抗剂疗法对佐林格-埃利森综合征有影响，链脲佐菌素和生长抑素类似物可分别控制肿瘤生长和内分泌综合征。
