Watson R G, Johnston C F, O'Hare M M, Anderson J R, Wilson B G, Collins J S, Sloan J M, Buchanan K D
Department of Medicine, Queen's University of Belfast.
Q J Med. 1989 Jul;72(267):647-57.
The reported incidence of gastrointestinal endocrine tumours is variable. In Northern Ireland circumstances allowing such an assessment are favourable with a central diagnostic laboratory and register established to collect data on tumours from a well-defined population of 1.5 million people. From 1970 to 1985, 368 cases were recorded of which 85 per cent were carcinoid tumours. The annual incidence of carcinoid tumours was 1.3 per 100,000 of the population and the majority occurred in the appendix (61 per cent). No patients presented with the carcinoid syndrome. The annual incidence for other tumours was 0.12 per 100,000 for insulinomas; islet cell tumours of unknown type 0.07; Zollinger-Ellison syndrome 0.05; and multiple endocrine neoplasia (MEN) 0.05. There were two cases of VIPoma, one glucagonoma, one neurotensinoma and one tumour producing ACTH. It is possible that some tumours are more uncommon than others because of difficulty in diagnosis.
胃肠道内分泌肿瘤的报告发病率各不相同。在北爱尔兰，具备进行此类评估的有利条件，设有一个中央诊断实验室和登记处，负责收集来自150万明确人口群体的肿瘤数据。1970年至1985年期间，共记录了368例病例，其中85%为类癌肿瘤。类癌肿瘤的年发病率为每10万人中有1.3例，且大多数发生在阑尾（61%）。没有患者出现类癌综合征。其他肿瘤的年发病率分别为：胰岛素瘤每10万人中有0.12例；未知类型的胰岛细胞瘤每10万人中有0.07例；佐林格 - 埃利森综合征每10万人中有0.05例；多发性内分泌腺瘤病（MEN）每10万人中有0.05例。有2例血管活性肠肽瘤、1例胰高血糖素瘤、1例神经降压素瘤和1例产生促肾上腺皮质激素的肿瘤。由于诊断困难可能导致某些肿瘤比其他肿瘤更为罕见
