Sardana Kabir, Verma Gunjan
Department of Dermatology & STD, PGIMER and Dr. Ram Manohar Lohia Hospital, New Delhi, India.
Indian J Dermatol. 2017 Jul-Aug;62(4):392-394. doi: 10.4103/ijd.IJD_483_16.
Acne vulgaris is one of the most commonly seen conditions and the immunological link is a topic of active research. Recently, the Th17 pathway has been found to play a pivotal role in acne. The adaptive immune response toward leads to activation of Th17 axis. Consequently, the Th17 cytokines (IL-17, IL-1 β, IL-6, and tumor growth factor, in turn, activate the various pathogenic steps in acne. Drugs such as Vitamin D3 and isotretinoin which target the Th17 pathway may offer an additional pathway for their therapeutic response.
寻常痤疮是最常见的病症之一，其免疫关联是一个活跃的研究课题。最近，发现Th17通路在痤疮中起关键作用。对……的适应性免疫反应导致Th17轴的激活。因此，Th17细胞因子（IL-17、IL-1β、IL-6和肿瘤生长因子）进而激活痤疮中的各种致病步骤。靶向Th17通路的药物如维生素D3和异维A酸可能为其治疗反应提供额外途径。 （注：原文中“toward leads to”表述有误，可能影响准确理解，这里按大致意思翻译）
