Firlej Ewelina, Kowalska Wioleta, Szymaszek Karolina, Roliński Jacek, Bartosińska Joanna
Department of Cosmetology and Aesthetic Medicine, Medical University of Lublin, 20-093 Lublin, Poland.
Department of Clinical Immunology, Medical University of Lublin, 20-093 Lublin, Poland.
J Clin Med. 2022 Mar 13;11(6):1579. doi: 10.3390/jcm11061579.
Acne vulgaris is a skin disease that often occurs in adolescence and in young adulthood. The main pathogenic factors are hyperkeratinization, obstruction of sebaceous glands, stimulation of sebaceous gland secretion by androgens, and bacterial colonization of sebaceous units by , which promotes inflammation. Little is known about the role of skin immune cells in the development of acne lesions. The aim of the study was to try to understand the role of skin immune cells in the course of acne. Recent studies have shown that there are at least four major pathways by which interacts with the innate immune system to induce inflammation: through TLRs, activating inflammasomes, inducing the production of matrix metalloproteinases (MMPs), and stimulating antimicrobial peptide (AMP) activity. Cells of adaptive immune response, mainly Th1 and Th17 lymphocytes, also play an important role in the pathogenesis of acne. It is worth emphasizing that understanding the role of the skin's immune cells in the pathogenesis of acne may, in the future, contribute to the application of modern therapeutic strategies that would avoid addiction to antibiotics, which would alleviate the spectrum of resistance that is now evident and a current threat.
寻常痤疮是一种常发生于青春期和青年期的皮肤病。主要致病因素包括过度角化、皮脂腺阻塞、雄激素刺激皮脂腺分泌以及痤疮丙酸杆菌在皮脂腺单位的定植，从而引发炎症。关于皮肤免疫细胞在痤疮皮损发展过程中的作用，人们了解甚少。本研究的目的是试图了解皮肤免疫细胞在痤疮病程中的作用。最近的研究表明，痤疮丙酸杆菌与先天免疫系统相互作用以诱导炎症至少有四条主要途径：通过Toll样受体（TLRs）、激活炎性小体、诱导基质金属蛋白酶（MMPs）的产生以及刺激抗菌肽（AMP）活性。适应性免疫反应的细胞，主要是Th1和Th17淋巴细胞，在痤疮发病机制中也起重要作用。值得强调的是，了解皮肤免疫细胞在痤疮发病机制中的作用，未来可能有助于应用现代治疗策略，避免对抗生素产生依赖，这将缓解目前明显的耐药谱以及当前面临的威胁。
