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相似文献

1
Risperidone-induced reversible neutropenia.利培酮所致可逆性中性粒细胞减少症。
Neuropsychiatr Dis Treat. 2017 Jul 25;13:1975-1977. doi: 10.2147/NDT.S141472. eCollection 2017.
2
[Neutropenia in a patient treated with clozapine in combination with other psychotropic drugs].[使用氯氮平联合其他精神药物治疗的患者出现中性粒细胞减少症]
Encephale. 2002 Nov-Dec;28(6 Pt 1):567-9.
3
Risperidone appears safe in patients with antipsychotic-induced blood dyscrasias.利培酮在患有抗精神病药物引起的血液系统异常的患者中似乎是安全的。
Int Clin Psychopharmacol. 1996 Mar;11(1):53-4. doi: 10.1097/00004850-199603000-00007.
4
Strategies for switching from conventional antipsychotic drugs or risperidone to olanzapine.从传统抗精神病药物或利培酮转换为奥氮平的策略。
J Clin Psychiatry. 2000 Nov;61(11):833-40. doi: 10.4088/jcp.v61n1105.
5
Risperidone-induced leukopenia: a case report and brief review of literature.利培酮致白细胞减少症 1 例报告并文献复习
Gen Hosp Psychiatry. 2013 Jan-Feb;35(1):102.e3-6. doi: 10.1016/j.genhosppsych.2012.03.009. Epub 2012 Apr 18.
6
The impact upon extra-pyramidal side effects, clinical symptoms and quality of life of a switch from conventional to atypical antipsychotics (risperidone or olanzapine) in elderly patients with schizophrenia.从传统抗精神病药物转换为非典型抗精神病药物（利培酮或奥氮平）对老年精神分裂症患者锥体外系副作用、临床症状及生活质量的影响。
Int J Geriatr Psychiatry. 2003 May;18(5):432-40. doi: 10.1002/gps.862.
7
Olanzapine-induced and Risperidone-induced Leukopenia: A Case of Synergistic Adverse Reaction?奥氮平所致及利培酮所致白细胞减少症：一例协同不良反应病例？
J Psychiatr Pract. 2018 Mar;24(2):121-124. doi: 10.1097/PRA.0000000000000292.
8
Reversible neutropenia during a cold: possible involvement of risperidone? A case report.感冒期间的可逆性中性粒细胞减少症：利培酮可能与之有关？病例报告。
Eur Neuropsychopharmacol. 1995 Mar;5(1):1-2; discussion 3. doi: 10.1016/0924-977x(94)00125-u.
9
Risperidone-Induced Neutropenia in a Schizophrenic Patient: A Case Report and Literature Review.一名精神分裂症患者的利培酮所致中性粒细胞减少症：病例报告及文献综述
Case Rep Psychiatry. 2021 Aug 17;2021:3980872. doi: 10.1155/2021/3980872. eCollection 2021.
10
Severe hyperglycemia induced by olanzapine was improved with a recovery of insulin secretion after switching to risperidone and introducing insulin therapy.换用利培酮并引入胰岛素治疗后，奥氮平所致的严重高血糖得到改善，胰岛素分泌恢复。
Intern Med. 2010;49(23):2635-7. doi: 10.2169/internalmedicine.49.4397. Epub 2010 Dec 1.

引用本文的文献

1
Risperidone-Induced Neutropenia in a Schizophrenic Patient: A Case Report and Literature Review.一名精神分裂症患者的利培酮所致中性粒细胞减少症：病例报告及文献综述
Case Rep Psychiatry. 2021 Aug 17;2021:3980872. doi: 10.1155/2021/3980872. eCollection 2021.
2
Paliperidone induced neutropenia in first episode psychosis: a case report.帕利哌酮致首发精神分裂症患者中性粒细胞减少 1 例报告
BMC Psychiatry. 2021 Feb 6;21(1):76. doi: 10.1186/s12888-021-03073-w.
3
Immunoendocrine Peripheral Effects Induced by Atypical Antipsychotics.非典型抗精神病药物引起的免疫内分泌外周效应。
Front Endocrinol (Lausanne). 2020 Apr 21;11:195. doi: 10.3389/fendo.2020.00195. eCollection 2020.

本文引用的文献

1
Risperidone-induced leukopenia: a case report and brief review of literature.利培酮致白细胞减少症 1 例报告并文献复习
Gen Hosp Psychiatry. 2013 Jan-Feb;35(1):102.e3-6. doi: 10.1016/j.genhosppsych.2012.03.009. Epub 2012 Apr 18.
2
Risperidone modulates the cytokine and chemokine release of dendritic cells and induces TNF-α-directed cell apoptosis in neutrophils.利培酮调节树突状细胞的细胞因子和趋化因子释放，并诱导中性粒细胞中 TNF-α 定向的细胞凋亡。
Int Immunopharmacol. 2012 Jan;12(1):197-204. doi: 10.1016/j.intimp.2011.11.011. Epub 2011 Dec 5.
3
Haematological toxicity of clozapine and some other drugs used in psychiatry.氯氮平及其他一些精神科用药的血液学毒性
Hum Psychopharmacol. 2011 Mar;26(2):112-9. doi: 10.1002/hup.1181. Epub 2011 Mar 17.
4
Effects of lactational exposure of olanzapine and risperidone on hematology and lymphoid organs histopathology: a comparative study in mice neonates.奥氮平与利培酮哺乳期暴露对血液学和淋巴器官组织病理学的影响：新生期小鼠的比较研究。
Eur J Pharmacol. 2010 May 25;634(1-3):170-7. doi: 10.1016/j.ejphar.2010.02.014. Epub 2010 Feb 20.
5
Leukopenia during therapy with risperidone long-acting injectable: two case reports.长效注射用利培酮治疗期间的白细胞减少症：两例病例报告。
J Clin Psychopharmacol. 2008 Dec;28(6):713-4. doi: 10.1097/JCP.0b013e31818b53a1.
6
[Leukopenia associated to the use of risperidone: a case report and review of the literature].[使用利培酮相关的白细胞减少症：一例病例报告及文献综述]
Rev Clin Esp. 2006 Mar;206(3):162-3. doi: 10.1157/13086216.
7
Increased FasL expression correlates with apoptotic changes in granulocytes cultured with oxidized clozapine.FasL表达增加与用氧化氯氮平培养的粒细胞中的凋亡变化相关。
Toxicol Appl Pharmacol. 2006 Aug 1;214(3):326-34. doi: 10.1016/j.taap.2006.01.008. Epub 2006 Feb 28.
8
Risperidone-induced leucopenia and neutropenia: a case report.利培酮所致白细胞减少症和中性粒细胞减少症：一例报告
Eur Psychiatry. 2004 Apr;19(2):117. doi: 10.1016/j.eurpsy.2003.03.009.
9
Risperidone induced cytopenias.利培酮引起血细胞减少。
J Assoc Physicians India. 2000 Nov;48(11):1122-3.
10
[A case of leukopenia in treatment with risperidone in an adolescent].[青少年使用利培酮治疗过程中出现白细胞减少症1例]
Encephale. 2000 Sep-Oct;26(5):81-4.

利培酮所致可逆性中性粒细胞减少症。

Risperidone-induced reversible neutropenia.

作者信息

Kattalai Kailasam Vasanth, Chima Victoria, Nnamdi Uchechukwu, Sharma Kavita, Shah Kairav

机构信息

College of Medicine, University of Illinois, Chicago, IL, USA.

Mount Sinai Beth Israel Medical Center, New York, NY, USA.

出版信息

Neuropsychiatr Dis Treat. 2017 Jul 25;13:1975-1977. doi: 10.2147/NDT.S141472. eCollection 2017.

DOI:10.2147/NDT.S141472
PMID:28794632
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5536090/
Abstract

This case report presents a 44-year-old man with a history of schizophrenia who developed neutropenia on risperidone therapy. The patient's laboratory reports showed a gradual decline of leukocytes and neutrophils after resolution and rechallenging. This was reversed with the discontinuation of risperidone and by switching to olanzapine. In this case report, we also discuss the updated evidence base for management of risperidone-induced neutropenia.

摘要

本病例报告介绍了一名44岁有精神分裂症病史的男性，其在接受利培酮治疗时出现了中性粒细胞减少症。患者的实验室报告显示，在缓解和再次用药后白细胞和中性粒细胞逐渐下降。停用利培酮并换用奥氮平后这种情况得到了逆转。在本病例报告中，我们还讨论了利培酮所致中性粒细胞减少症管理的最新证据基础。