利培酮所致可逆性中性粒细胞减少症。
Risperidone-induced reversible neutropenia.
作者信息
Kattalai Kailasam Vasanth, Chima Victoria, Nnamdi Uchechukwu, Sharma Kavita, Shah Kairav
机构信息
College of Medicine, University of Illinois, Chicago, IL, USA.
Mount Sinai Beth Israel Medical Center, New York, NY, USA.
出版信息
Neuropsychiatr Dis Treat. 2017 Jul 25;13:1975-1977. doi: 10.2147/NDT.S141472. eCollection 2017.
Abstract
This case report presents a 44-year-old man with a history of schizophrenia who developed neutropenia on risperidone therapy. The patient's laboratory reports showed a gradual decline of leukocytes and neutrophils after resolution and rechallenging. This was reversed with the discontinuation of risperidone and by switching to olanzapine. In this case report, we also discuss the updated evidence base for management of risperidone-induced neutropenia.
摘要
本病例报告介绍了一名44岁有精神分裂症病史的男性，其在接受利培酮治疗时出现了中性粒细胞减少症。患者的实验室报告显示，在缓解和再次用药后白细胞和中性粒细胞逐渐下降。停用利培酮并换用奥氮平后这种情况得到了逆转。在本病例报告中，我们还讨论了利培酮所致中性粒细胞减少症管理的最新证据基础。
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Immunoendocrine Peripheral Effects Induced by Atypical Antipsychotics.非典型抗精神病药物引起的免疫内分泌外周效应。
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本文引用的文献
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Risperidone-induced leukopenia: a case report and brief review of literature.利培酮致白细胞减少症 1 例报告并文献复习
Gen Hosp Psychiatry. 2013 Jan-Feb;35(1):102.e3-6. doi: 10.1016/j.genhosppsych.2012.03.009. Epub 2012 Apr 18.
2
Risperidone modulates the cytokine and chemokine release of dendritic cells and induces TNF-α-directed cell apoptosis in neutrophils.利培酮调节树突状细胞的细胞因子和趋化因子释放，并诱导中性粒细胞中 TNF-α 定向的细胞凋亡。
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Leukopenia during therapy with risperidone long-acting injectable: two case reports.长效注射用利培酮治疗期间的白细胞减少症：两例病例报告。
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[Leukopenia associated to the use of risperidone: a case report and review of the literature].[使用利培酮相关的白细胞减少症：一例病例报告及文献综述]
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