β受体阻滞剂的急性肾脏效应。

Acute renal effects of beta-blockers.

作者信息

Zech P, Pozet N, Labeeuw M, Laville M, Hadj-Aissa A, Arkouche W, Poncet J F

出版信息

Am J Nephrol. 1986;6 Suppl 2:15-9. doi: 10.1159/000167327.

Abstract

The effects on renal function of a single dose of six different beta-blockers (atenolol, propranolol, metoprolol, acebutolol, nadolol, and pindolol) have been evaluated in 51 hypertensive patients with normal glomerular filtration rate (GFR). Most drugs, except pindolol, induce a 10-20% decrease in GFR and renal plasma flow, although differences in the magnitude and the pattern of this fall are evident. The fractional excretion of sodium is generally depressed by 20-40%. These data suggest a limited renal tolerance of most beta-blockers during acute administration, irrespective of their pharmacological characteristics.

摘要

在51名肾小球滤过率（GFR）正常的高血压患者中，评估了单剂量六种不同β受体阻滞剂（阿替洛尔、普萘洛尔、美托洛尔、醋丁洛尔、纳多洛尔和吲哚洛尔）对肾功能的影响。除吲哚洛尔外，大多数药物会使GFR和肾血浆流量降低10%-20%，尽管这种下降的幅度和模式存在明显差异。钠的分数排泄通常会降低20%-40%。这些数据表明，在急性给药期间，大多数β受体阻滞剂的肾脏耐受性有限，无论其药理特性如何。