Walters L, Dormehl I, Goosen D J, Avenant J C, Du Plessis M, Jacobs N, Schoeman H S
S Afr Med J. 1983 Oct 1;64(15):572-3.
A baboon model was used to investigate the effects of atenolol, nadolol, sotalol and labetalol on renal function. The glomerular filtration rate (GFR) and renal blood flow (RBF) were measured, using radionuclides and a gamma camera, before and after 1 week's oral administration of these drugs. All the drugs caused an increase in the GFR, but this reached statistical significance only in the cases of sotalol (P less than 0,025) and labetalol (0,05 less than P less than 0,10). The RBF was not significantly changed, although it decreased in all cases.
使用狒狒模型研究阿替洛尔、纳多洛尔、索他洛尔和拉贝洛尔对肾功能的影响。在口服这些药物1周前后，使用放射性核素和γ相机测量肾小球滤过率（GFR）和肾血流量（RBF）。所有药物均使GFR升高，但仅索他洛尔（P＜0.025）和拉贝洛尔（0.05＜P＜0.10）的情况达到统计学显著水平。RBF虽在所有情况下均降低，但无显著变化。
