Zech P, Pozet N, Labeeuw M, Sassard J, Bernheim J, Pellet M, Traeger J
Proc Eur Dial Transplant Assoc. 1976;12:203-9.
The effects of two new beta blockers on renal function have been studied. There were significant decreases in urine flow, urea clearance, sodium and chloride excretion rates after acute administration. Fractional excretion of sodium (FeNa) fell significantly but did not continue to fall during chronic administration. Blood pressure and plasma renin activity decreased significantly after two months' therapy. These findings suggest that beta blockers in patients with unstable cardiovascular function increase the need for concomitant diuretic therapy.
研究了两种新型β受体阻滞剂对肾功能的影响。急性给药后，尿流量、尿素清除率、钠和氯排泄率均显著下降。钠分数排泄（FeNa）显著下降，但在长期给药期间并未持续下降。经过两个月的治疗后，血压和血浆肾素活性显著降低。这些发现表明，心血管功能不稳定的患者使用β受体阻滞剂会增加同时使用利尿剂治疗的必要性。
