Damjuti Watchara, Fuangfoo Thanes, Palanuvej Chanida, Li Tingli, Ruangrungsi Nijsiri
Public Health Sciences Program, College of Public Health Sciences, Chulalongkorn University, Bangkok 10330, Thailand.
Department of Pharmacognosy and Pharmacology, Faculty of Pharmacy, Rangsit University, Pathum Thani 12000, Thailand.
J Adv Pharm Technol Res. 2017 Jul-Sep;8(3):97-101. doi: 10.4103/japtr.JAPTR_185_16.
Mast. (Restionaceae) is an edible plant which has indigenous warnings regarding its side effects which can manifest as dizziness. This study investigated hypnotic and anxiolytic properties using several animal models. Anxiolytic activities were evaluated using locomotor determination by elevated plus-maze test, open-field test, and rotarod performance test. Hypnotic activities were performed using pentobarbital sodium-induced sleeping time test. Sleep architecture and quality were obtained from sleep-wake analysis and nonrapid eye movement (NREM) delta activity using electroencephalography. An ethanolic extract of indicated effective potencies for hypnotic test, locomotor activities, and sleep-wake analysis. Ethanolic extract showed a dose relationship with sleeping time for pentobarbital-induced sleeping time test ( < 0.01) and also an antagonistic effect on shortening in sleep time induced by flumazenil. The consort significantly decreased locomotor activities among animals undergoing elevated plus-maze test, open-field test, and rotarod performance test, whereas sleep-wake analysis showed that sleeping time and NREM sleep increased. Ethanolic extract of was shown to be anxiolytic, with the possibly of benzodiazepine-like hypnotic activity.
马斯塔（帚灯草科）是一种可食用植物，关于其可能表现为头晕的副作用，当地有相关警示。本研究使用多种动物模型研究了其催眠和抗焦虑特性。通过高架十字迷宫试验、旷场试验和转棒试验的运动测定来评估抗焦虑活性。使用戊巴比妥钠诱导睡眠时间试验来进行催眠活性测试。通过脑电图从睡眠-觉醒分析和非快速眼动（NREM）δ活动获得睡眠结构和质量。[植物名称]的乙醇提取物在催眠试验、运动活动和睡眠-觉醒分析中显示出有效的效力。乙醇提取物在戊巴比妥诱导睡眠时间试验中显示出与睡眠时间的剂量关系（P<0.01），并且对氟马西尼诱导的睡眠时间缩短具有拮抗作用。该提取物在进行高架十字迷宫试验、旷场试验和转棒试验的动物中显著降低了运动活动，而睡眠-觉醒分析表明睡眠时间和NREM睡眠增加。[植物名称]的乙醇提取物被证明具有抗焦虑作用，可能具有类似苯二氮䓬类的催眠活性。
