Stamenov Georgi Stamenov, Parvanov Dimitar Angelov, Chaushev Todor Angelov
Department of Obstetrics and Gynecology, Nadezhda Women's Health Hospital, Sofia, Bulgaria.
Research Department, Nadezhda Women's Health Hospital, Sofia, Bulgaria.
Clin Exp Reprod Med. 2017 Jun;44(2):105-110. doi: 10.5653/cerm.2017.44.2.105. Epub 2017 Jun 30.
The purpose of this study was to evaluate the efficacy of frozen mixed double-embryo transfer (MDET; the simultaneous transfer of day 3 and day 5 embryos) in comparison with frozen blastocyst double-embryo transfer (BDET; transfer of two day 5 blastocysts) in patients with repeated implantation failure (RIF).
A total of 104 women with RIF who underwent frozen MDET (n=48) or BDET (n=56) with excellent-quality embryos were included in this retrospective analysis. All frozen embryo transfers were performed in natural cycles. The main outcome measures were the implantation rate, clinical pregnancy rate, multiple pregnancy rate, and miscarriage rate. These measures were compared between the patients who underwent MDET or BDET using the chi-square test or the Fisher exact test, as appropriate.
The implantation and clinical pregnancy rates were significantly higher in patients who underwent MDET than in those who underwent BDET (60.4% vs. 39.3%, =0.03 and 52.1% vs. 30.4%, =0.05, respectively). A significantly lower miscarriage rate was observed in the MDET group (6.9% vs. 10.7%, =0.05). In addition, the multiple pregnancy rate was slightly, but not significantly, higher in the MDET group (27.1% vs. 25.0%).
MDET was found to be significantly superior to double blastocyst transfer. It could be regarded as an appropriate approach to improve fertilization success rates in RIF patients.
本研究旨在评估冷冻混合双胚胎移植（MDET，即同时移植第3天和第5天胚胎）与冷冻囊胚双胚胎移植（BDET，即移植两个第5天囊胚）相比，对反复种植失败（RIF）患者的疗效。
本回顾性分析纳入了104例接受冷冻MDET（n = 48）或BDET（n = 56）且胚胎质量优良的RIF女性。所有冷冻胚胎移植均在自然周期进行。主要观察指标为种植率、临床妊娠率、多胎妊娠率和流产率。根据情况，使用卡方检验或Fisher精确检验对接受MDET或BDET的患者的这些指标进行比较。
接受MDET的患者的种植率和临床妊娠率显著高于接受BDET的患者（分别为60.4%对39.3%，P = 0.03；52.1%对30.4%，P = 0.05）。MDET组的流产率显著较低（6.9%对10.7%，P = 0.05）。此外，MDET组的多胎妊娠率略高，但无显著差异（27.1%对25.0%）。
发现MDET明显优于双囊胚移植。它可被视为提高RIF患者受精成功率的一种合适方法。
