Marioni Riccardo E, Ritchie Stuart J, Joshi Peter K, Hagenaars Saskia P, Okbay Aysu, Fischer Krista, Adams Mark J, Hill W David, Davies Gail, Nagy Reka, Amador Carmen, Läll Kristi, Metspalu Andres, Liewald David C, Campbell Archie, Wilson James F, Hayward Caroline, Esko Tõnu, Porteous David J, Gale Catharine R, Deary Ian J
Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh EH8 9JZ, United Kingdom;
Medical Genetics Section, Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, United Kingdom.
Proc Natl Acad Sci U S A. 2016 Nov 22;113(47):13366-13371. doi: 10.1073/pnas.1605334113. Epub 2016 Oct 31.
Educational attainment is associated with many health outcomes, including longevity. It is also known to be substantially heritable. Here, we used data from three large genetic epidemiology cohort studies (Generation Scotland, n = ∼17,000; UK Biobank, n = ∼115,000; and the Estonian Biobank, n = ∼6,000) to test whether education-linked genetic variants can predict lifespan length. We did so by using cohort members' polygenic profile score for education to predict their parents' longevity. Across the three cohorts, meta-analysis showed that a 1 SD higher polygenic education score was associated with ∼2.7% lower mortality risk for both mothers (total n = 79,702) and ∼2.4% lower risk for fathers (total n = 97,630). On average, the parents of offspring in the upper third of the polygenic score distribution lived 0.55 y longer compared with those of offspring in the lower third. Overall, these results indicate that the genetic contributions to educational attainment are useful in the prediction of human longevity.
受教育程度与包括长寿在内的许多健康结果相关。众所周知，受教育程度也具有很高的遗传性。在此，我们使用了三项大型遗传流行病学队列研究的数据（苏格兰世代研究，n = 约17000；英国生物银行，n = 约115000；以及爱沙尼亚生物银行，n = 约6000）来测试与教育相关的基因变异是否能够预测寿命长短。我们通过使用队列成员的教育多基因谱分数来预测其父母的长寿情况。在这三项队列研究中，荟萃分析表明，多基因教育分数每高出1个标准差，母亲（总计n = 79702）的死亡风险就降低约2.7%，父亲（总计n = 97630）的死亡风险则降低约2.4%。平均而言，多基因分数分布处于上三分之一的后代的父母比处于下三分之一的后代的父母寿命长0.55年。总体而言，这些结果表明，对受教育程度的遗传贡献有助于预测人类的长寿情况。
