使用酶修饰的碳纳米管柱在连续流动中进行H驱动的生物催化氢化反应。
H-Driven biocatalytic hydrogenation in continuous flow using enzyme-modified carbon nanotube columns.
作者信息
Zor Ceren, Reeve Holly A, Quinson Jonathan, Thompson Lisa A, Lonsdale Thomas H, Dillon Frank, Grobert Nicole, Vincent Kylie A
机构信息
Department of Chemistry, University of Oxford, Inorganic Chemistry Laboratory, South Parks Road, Oxford, OX1 3QR, UK.
Department of Materials, University of Oxford, Parks Road, Oxford, OX1 3PH, UK.
出版信息
Chem Commun (Camb). 2017 Aug 31;53(71):9839-9841. doi: 10.1039/c7cc04465h.
We describe the implementation of a system of immobilised enzymes for H-driven NADH recycling coupled to a selective biotransformation to enable H-driven biocatalysis in flow. This approach represents a platform that can be optimised for a wide range of hydrogenation steps and is shown here for enantioselective ketone reduction and reductive amination.
我们描述了一种固定化酶系统的实施，该系统用于与选择性生物转化偶联的H驱动的NADH循环，以实现流动体系中的H驱动生物催化。这种方法代表了一个可针对广泛氢化步骤进行优化的平台，本文展示了其在对映选择性酮还原和还原胺化中的应用。
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