Gu Se Hun, Song Dong Hyun, Lee Daesang, Jang Jeyoun, Kim Min Young, Jung Jaehun, Woo Koung In, Kim Mirang, Seog Woong, Oh Hong Sang, Choi Byung Seop, Ahn Jong-Seong, Park Quehn, Jeong Seong Tae
The 5th R&D Institute, Agency for Defense Development, Yuseong, P.O. Box 35, Daejeon, 34186, Republic of Korea.
Armed Forces Medical Research Institute, 90 Jaunro, Yuseong, Daejeon, 305-878, Republic of Korea.
Virus Genes. 2017 Dec;53(6):918-921. doi: 10.1007/s11262-017-1500-9. Epub 2017 Aug 9.
Zika virus (ZIKV) (genus Flavivirus, family Flaviviridae) is an emerging pathogen associated with microcephaly and Guillain-Barré syndrome. The rapid spread of ZIKV disease in over 60 countries and the large numbers of travel-associated cases have caused worldwide concern. Thus, intensified surveillance of cases among immigrants and tourists from ZIKV-endemic areas is important for disease control and prevention. In this study, using Next Generation Sequencing, we reported the first whole-genome sequence of ZIKV strain AFMC-U, amplified from the urine of a traveler returning to Korea from the Philippines. Phylogenetic analysis showed geographic-specific clustering. Our results underscore the importance of examining urine in the diagnosis of ZIKV infection.
寨卡病毒（ZIKV）（黄病毒属，黄病毒科）是一种与小头畸形和吉兰-巴雷综合征相关的新兴病原体。寨卡病毒病在60多个国家迅速传播，以及大量与旅行相关的病例已引起全球关注。因此，加强对来自寨卡病毒流行地区的移民和游客中的病例监测对于疾病控制和预防很重要。在本研究中，我们使用下一代测序技术报告了从一名从菲律宾返回韩国的旅行者尿液中扩增出的寨卡病毒株AFMC-U的首个全基因组序列。系统发育分析显示出地理特异性聚类。我们的结果强调了在寨卡病毒感染诊断中检测尿液的重要性。
