Infectious Disease Control and Environmental Health, Norwegian Institute of Public Health, Oslo, Norway.
Marie Bashir Institute for Infectious Diseases and Biosecurity, Charles Perkins Centre, School of Life and Environmental Sciences and Sydney Medical School, University of Sydney, Sydney, NSW, 2006, Australia.
Emerg Microbes Infect. 2018 May 9;7(1):79. doi: 10.1038/s41426-018-0082-5.
Based on serological evidence and viral isolation, Zika virus (ZIKV) has circulated for many years relatively benignly in a sylvatic cycle in Africa and an urban cycle in South East Asia (SEA). With the recent availability of limited but novel Indian ZIKV sequences to add to the plethora of SEA sequences, we traced the phylogenetic history and spatio-temporal dispersal pattern of ZIKV in Asia prior to its explosive emergence in the Pacific region and the Americas. These analyses demonstrated that the introduction and dispersal of ZIKV on the Pacific islands were preceded by an extended period of relatively silent transmission in SEA, enabling the virus to expand geographically and evolve adaptively before its unanticipated introduction to immunologically naive populations on the Pacific islands and in the Americas. Our findings reveal new features of the evolution and dispersal of this intriguing virus and may benefit future disease control strategies.
基于血清学证据和病毒分离，寨卡病毒（ZIKV）在非洲的丛林循环和东南亚的城市循环中已经相对良性地传播了很多年。随着最近有限但新颖的印度寨卡病毒序列的出现，加上大量的东南亚序列，我们追溯了寨卡病毒在其在太平洋地区和美洲爆炸性出现之前在亚洲的系统发育历史和时空扩散模式。这些分析表明，太平洋岛屿上寨卡病毒的引入和传播之前，在东南亚地区有一个相对较长的沉默传播期，使病毒在其意外引入太平洋岛屿和美洲的免疫幼稚人群之前，能够在地理上扩张并适应性进化。我们的研究结果揭示了这种引人入胜的病毒的进化和传播的新特征，可能有助于未来的疾病控制策略。
