College of Osteopathic Medicine, Oklahoma State University, 1111 West 17th Street, Tulsa, OK, 74107, USA.
Department of Biology, East Central University, 1100 East 14th Street, Box N-5, Ada, OK, 74820, USA.
Mycopathologia. 2017 Dec;182(11-12):1025-1036. doi: 10.1007/s11046-017-0188-7. Epub 2017 Aug 9.
Indoor mold due to water damage causes serious human respiratory disorders, and the remediation to homes, schools, and businesses is a major expense. Prevention of mold infestation of building materials would reduce health problems and building remediation costs. Nonsteroidal anti-inflammatory drugs (NSAIDs) inhibit yeasts and a limited number of filamentous fungi. The purpose of this research was to determine the possible inhibitory activity of nonsteroidal anti-inflammatory drugs (NSAIDs) on germination, fungal growth, and reproduction of Chaetomium globosum and other important filamentous fungi that occur in water-damaged buildings. Several NSAIDs were found to inhibit C. globosum germination, growth, and reproduction. The most effective NSAIDs inhibiting C. globosum were ibuprofen, diflunisal, and diclofenac. Fusarium oxysporum, Fusarium solani, Aspergillus niger, and Stachybotrys atra were also tested on the various media with similar results obtained. However, F. oxysporum and A. niger exhibited a higher level of resistance to aspirin and NaSAL when compared to the C. globosum isolates. The inhibition exhibited by NSAIDs was variable depending on growth media and stage of fungal development. These compounds have a great potential of inhibiting fungal growth on building materials such as gypsum board. Formulations of sprays or building materials with NSAID-like chemical treatments may hold promise in reducing mold in homes and buildings.
室内霉菌因水损害导致严重的人类呼吸道紊乱，对家庭、学校和企业进行修复是一项重大开支。预防建筑材料的霉菌滋生将减少健康问题和建筑修复成本。非甾体抗炎药（NSAIDs）抑制酵母和少数丝状真菌。本研究的目的是确定非甾体抗炎药（NSAIDs）对在水损害建筑物中发生的 Chaetomium globosum 和其他重要丝状真菌的萌发、真菌生长和繁殖的可能抑制活性。发现几种 NSAIDs 抑制 C. globosum 的萌发、生长和繁殖。抑制 C. globosum 最有效的 NSAIDs 是布洛芬、双氯芬酸和二氟尼柳。还在各种培养基上测试了腐霉（Fusarium oxysporum）、茄病镰刀菌（Fusarium solani）、黑曲霉（Aspergillus niger）和烟曲霉（Stachybotrys atra），并获得了类似的结果。然而，与 C. globosum 分离株相比，腐霉和黑曲霉对阿司匹林和 NaSAL 的抗性更高。NSAIDs 的抑制作用取决于生长培养基和真菌发育阶段而有所不同。这些化合物具有抑制石膏板等建筑材料上真菌生长的巨大潜力。含有 NSAID 类化学处理的喷雾剂或建筑材料的配方可能有望减少家庭和建筑物中的霉菌。
