Perveen Shagufta, Al-Taweel Areej Mohammad, Yusufoglu Hasan Soliman, Fawzy Ghada Ahmed, Foudah Ahmed, Abdel-Kader Maged Saad
Department of Pharmacognosy, College of Pharmacy, King Saud University, P. O. Box 22452, Riyadh, 11495, Kingdom of Saudi Arabia.
Department of Pharmacognosy, College of Pharmacy, Prince Sattam Bin Abdulaziz University, P.O. Box 173, Al-Kharj, 11942, Saudi Arabia.
J Nat Med. 2018 Jan;72(1):106-117. doi: 10.1007/s11418-017-1118-1. Epub 2017 Aug 9.
Anvillea garcinii is a medicinal plant traditionally used for the treatment of dysentery, gastrointestinal troubles, hepatitis, lung disease, colds, digestive problems and pulmonary affections and in liver diseases. Four new sesquiterpene lactones, garcinamines A-D, along with seven known compounds, were isolated from the leaves of A. garcinii. This is the first report of the isolation of amino acid analogues of parthenolide-type sesquiterpene lactones from the family Asteraceae. Total ethanol extract of leaves as well as the chloroform and n-butanol fractions were tested for their hepatoprotective effect using the carbon tetrachloride liver toxicity model. The chloroform fraction, at a dose of 400 mg/kg, demonstrated a significant hepatoprotective effect comparable to silymarin in all serum and tissue parameters. The cytotoxicity of all extracts and compounds were evaluated against five human cancer cell lines: MCF-7, HCT-116, HepG2, Hela and A-549. The results indicated that the chloroform and n-butanol fractions and compounds 3, 4, 7 and 8 displayed significant cytotoxic activity against these cell lines.
加氏安维尔草是一种药用植物，传统上用于治疗痢疾、胃肠道疾病、肝炎、肺病、感冒、消化问题和肺部疾病以及肝脏疾病。从加氏安维尔草的叶子中分离出了四种新的倍半萜内酯，即加氏胺A - D，以及七种已知化合物。这是首次从菊科植物中分离出小白菊内酯型倍半萜内酯的氨基酸类似物的报道。使用四氯化碳肝毒性模型对叶子的总乙醇提取物以及氯仿和正丁醇馏分进行了肝保护作用测试。氯仿馏分在剂量为400 mg/kg时，在所有血清和组织参数方面均表现出与水飞蓟宾相当的显著肝保护作用。评估了所有提取物和化合物对五种人类癌细胞系的细胞毒性：MCF - 7、HCT - 116、HepG2、Hela和A - 549。结果表明，氯仿和正丁醇馏分以及化合物3、4、7和8对这些细胞系表现出显著的细胞毒性活性。
