a Department of Medical Biochemistry , Health Sciences University, Kanuni Training and Research Hospital , Trabzon , Turkey.
b Department of Infection Diseases and Clinic Microbiology , Recep Tayyip Erdoğan University Medical Faculty , Rize , Turkey.
Arch Physiol Biochem. 2018 Feb;124(1):69-74. doi: 10.1080/13813455.2017.1361449. Epub 2017 Aug 10.
Crimean-Congo haemorrhagic fever (CCHF) is a life-threatening acute febrile haemorrhagic disease.
This study was to measure levels of the oxidative stress biomarkers malondialdehyde (MDA), total oxidant status (TOS), total antioxidant status (TAS) and oxidative stress index (OSI) and of CA I-II autoantibodies as biomarkers for autoimmunity and course of disease in patients with CCHF.
Seventy CCHF patients and 39 healthy control volunteers were included in the study.
Serum MDA and TAS levels were significantly higher (p < .0001) and serum TOS and OSI levels were significantly lower (p < .0001) in both the acute period and at 6th-month follow-up in the CCHF patients compared to the healthy volunteers. CA II levels were significantly higher in the acute period compared to the healthy volunteers (p < .005) and were significantly lower at 6th-month follow-up (p < .05).
Serum MDA and CA II autoantibodies appear to reflect oxidative stress status and disease progression in CCHF and may be used as biomarkers for oxidative stress and disease progression.
克里米亚-刚果出血热（CCHF）是一种危及生命的急性发热性出血性疾病。
本研究旨在测量氧化应激生物标志物丙二醛（MDA）、总氧化剂状态（TOS）、总抗氧化状态（TAS）和氧化应激指数（OSI）以及 CA I-II 自身抗体的水平，作为 CCHF 患者自身免疫和疾病进程的生物标志物。
本研究纳入了 70 例 CCHF 患者和 39 名健康对照志愿者。
与健康志愿者相比，CCHF 患者在急性期和 6 个月随访时血清 MDA 和 TAS 水平显著升高（p<0.0001），血清 TOS 和 OSI 水平显著降低（p<0.0001）。CA II 水平在急性期显著高于健康志愿者（p<0.005），而在 6 个月随访时显著降低（p<0.05）。
血清 MDA 和 CA II 自身抗体似乎反映了 CCHF 中的氧化应激状态和疾病进展，可作为氧化应激和疾病进展的生物标志物。
