急性前葡萄膜炎患者血清抗碳酸酐酶抗体与氧化应激-抗氧化平衡
Serum anti-carbonic anhydrase antibodies and oxidant-antioxidant balance in patients with acute anterior uveitis.
作者信息
Turk Adem, Aykut Murat, Akyol Nurettin, Kola Mehmet, Mentese Ahmet, Sumer Aysegul, Alver Ahmet, Erdol Hidayet
机构信息
Department of Ophthalmology, Karadeniz Technical University, School of Medicine , Trabzon , Turkey .
出版信息
Ocul Immunol Inflamm. 2014 Apr;22(2):127-32. doi: 10.3109/09273948.2013.830753. Epub 2013 Sep 24.
PURPOSE
To study the existence of anti-carbonic anhydrase antibodies (anti-CA-I&II) in acute anterior uveitis (AAU) patients and to analyze the relationship between the levels of these antibodies and the total antioxidant capacity (TAC), total oxidant capacity (TOC), oxidative stress index (OSI), and malondialdehyde (MDA) level.
METHODS
Forty-five AAU cases and 43 healthy controls were enrolled in this prospective study.
RESULTS
The average anti-CA I and II antibody levels were 0.433 ± 0.306 and 0.358 ± 0.261 IU/mL, respectively, in the AAU group and 0.275 ± 0.147 and 0.268 ± 0.108 IU/mL, respectively, in the control group (p = 0.004 and p = 0.036, respectively). In addition, it was found that the TOC, OSI, and MDA levels in the AAU subjects were statistically significantly higher than those of the control subjects.
CONCLUSIONS
These results suggest that autoimmune responses against CA I and CA II and an altered serum oxidant-antioxidant balance may be involved in the pathogenesis of AAU.
目的
研究急性前葡萄膜炎（AAU）患者中抗碳酸酐酶抗体（抗CA - I和II）的存在情况，并分析这些抗体水平与总抗氧化能力（TAC）、总氧化能力（TOC）、氧化应激指数（OSI）和丙二醛（MDA）水平之间的关系。
方法
本前瞻性研究纳入了45例AAU患者和43名健康对照者。
结果
AAU组抗CA I和II抗体的平均水平分别为0.433±0.306和0.358±0.261 IU/mL，对照组分别为0.275±0.147和0.268±0.108 IU/mL（p分别为0.004和0.036）。此外，发现AAU患者的TOC、OSI和MDA水平在统计学上显著高于对照组。
结论
这些结果表明，针对CA I和CA II的自身免疫反应以及血清氧化 - 抗氧化平衡的改变可能参与了AAU的发病机制。
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