实验动物咬伤过敏反应：全国性调查：第 1 部分：病例系列及文献复习。
Laboratory Animal Bite Anaphylaxis: A National Survey: Part 1: Case Series and Review of the Literature.
机构信息
Division of Occupational and Environmental Medicine, Department of Community and Family Medicine, Duke University Medical Center, Durham, North Carolina.
出版信息
J Occup Environ Med. 2017 Aug;59(8):728-738. doi: 10.1097/JOM.0000000000001005.
OBJECTIVE
This study documents previously unreported cases of laboratory animal bite anaphylaxis in animal laboratory facilities in the United States.
METHODS
An online survey was e-mailed to designated institutional officials at laboratory animal facilities identified by the National Institutes of Health Office of Laboratory Animal Welfare.
RESULTS
One hundred ninety eight organizations responded and 15 organizations indicated that workers had experienced anaphylaxis following an animal bite. Case report forms were completed by nine of these institutions for 14 cases, 13 for rodent bites, and one involving a needlestick from a horse. In half of the cases involving rodents, there was no prior history of animal allergy. All workers had uncomplicated recoveries. Treatment, testing, and work restrictions varied across cases.
CONCLUSIONS
While uncommon, anaphylaxis from laboratory animal bites occurs more frequently than suggested by the literature.
目的
本研究记录了美国动物实验室设施中实验室动物咬伤过敏反应的先前未报告病例。
方法
通过电子邮件向美国国立卫生研究院动物福利办公室确定的动物实验室设施的指定机构官员发送了在线调查。
结果
198 个组织做出了回应，其中 15 个组织表示工人在被动物咬伤后出现了过敏反应。其中 9 个机构完成了针对 14 例病例的病例报告表，其中 13 例涉及啮齿动物咬伤，1 例涉及马造成的针刺伤。在涉及啮齿动物的一半病例中，没有动物过敏的既往史。所有工人均康复顺利。治疗、检测和工作限制因病例而异。
结论
虽然不常见，但实验室动物咬伤引起的过敏反应比文献报道的更为常见。
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