Hesford J D, Platts-Mills T A, Edlich R F
Department of Plastic Surgery, University of Virginia School of Medicine, Charlottesville 22908, USA.
J Emerg Med. 1995 Nov-Dec;13(6):765-8. doi: 10.1016/0736-4679(95)02016-0.
Workers exposed to laboratory animals are at risk of developing asthma, rhinitis, angioedema, conjunctivitis, and urticaria. Approximately one in five scientists and technicians handling small animals will develop laboratory animal allergy symptoms within three years of employment, many of whom will have severe symptoms requiring a change of occupation. Individuals suffering from allergy to environmental allergens, such as pollen and ragweed, are more likely to develop allergic reactions to animals, and are more likely to develop asthma. We report a case of life-threatening anaphylaxis secondary to a rat bite in a laboratory research director with known allergies to rat urinary protein. While rodent bites are common in research settings, such severe reactions are extremely rare.
接触实验动物的工作人员有患哮喘、鼻炎、血管性水肿、结膜炎和荨麻疹的风险。在处理小动物的科学家中，约五分之一的人在入职三年内会出现实验动物过敏症状，其中许多人会出现严重症状，需要更换职业。对环境过敏原（如花粉和豚草）过敏的人更容易对动物产生过敏反应，也更容易患哮喘。我们报告一例在一名已知对大鼠尿蛋白过敏的实验室研究主任中，因被大鼠咬伤继发危及生命的过敏反应的病例。虽然在研究环境中啮齿动物咬伤很常见，但如此严重的反应极为罕见。
