Zhang Yaxia, Rosenberg Andrew E
Department of Pathology, Lerner College of Medicine, Robert J. Tomsich Pathology and Laboratory Medicine Institute, Cleveland Clinic, 9500 Euclid Avenue L25, Cleveland, OH 44195, USA.
Department of Pathology, Miller School of Medicine, University of Miami, 1400 Northwest 12th Avenue, Miami, FL 33136, USA.
Surg Pathol Clin. 2017 Sep;10(3):513-535. doi: 10.1016/j.path.2017.04.006. Epub 2017 Jun 29.
Bone-forming tumors are defined by neoplastic cells that differentiate along the lines of osteoblasts that deposit neoplastic bone. The morphology and biological spectrum of bone-forming tumors is broad, and their accurate diagnosis requires the careful correlation of their clinical, morphologic, and radiologic characteristics. Immunohistochemical and molecular analyses have an important role in select instances. At present, the identification of neoplastic bone largely depends on histologic analysis, which can be subjective. The major types of osteosarcoma are defined according to their morphology, origin within or on the surface of the bone, and their histologic grade.
成骨性肿瘤是由沿着成骨细胞系分化并沉积肿瘤性骨的肿瘤细胞所定义的。成骨性肿瘤的形态学和生物学谱很广，其准确诊断需要仔细关联其临床、形态学和放射学特征。免疫组织化学和分子分析在特定情况下具有重要作用。目前，肿瘤性骨的识别很大程度上依赖于组织学分析，而这可能具有主观性。骨肉瘤的主要类型是根据其形态、在骨内或骨表面的起源以及组织学分级来定义的。
