Centre for Applied Molecular Biology (CAMB), 87-West Canal Bank Road Thokar Niaz Baig, University of the Punjab, Lahore, Pakistan.
Centre for Applied Molecular Biology (CAMB), 87-West Canal Bank Road Thokar Niaz Baig, University of the Punjab, Lahore, Pakistan.
Eur J Intern Med. 2017 Oct;44:12-18. doi: 10.1016/j.ejim.2017.08.001. Epub 2017 Aug 7.
Zika virus (ZIKV) is a global threat because it is spreading at an alarming rate because of its wider range of transmission routes. The neuroteratogenic nature of ZIKV infection is posing serious threats to unborn lives therefore, it is necessary to develop an ideal ZIKV prophylactic or therapeutic agent urgently. Researchers are having tough time finding a treatment for ZIKV in part because of serious consequences of vaccines and drugs to unborn lives and pregnant women. However, in vitro and in vivo evaluation of therapeutic efficacy of DNA vaccine, recombinant subunit vaccine, and ZIKV purified inactivated vaccine offers hope for human protection. Large number of food and drug administration (FDA) approved drugs as wells as compounds with anti-ZIKV activity offer valuable opportunity to control the massive bio-burden of this catastrophic epidemic. Some evidences suggest that immunotherapeutics might prove to be winning strategy in pregnant females. Here, we review the recent advances and current knowledge regarding therapeutic interventions against ZIKV infection. This article will provide baseline data and roadmap to prosecute further research for the development of novel therapeutic strategy to curb the explosive rise in ZIKV.
寨卡病毒（ZIKV）是一种全球性威胁，因为它的传播途径更广，传播速度令人震惊。ZIKV 感染的神经致畸性质对未出生的生命构成了严重威胁，因此迫切需要开发理想的 ZIKV 预防或治疗药物。研究人员在寻找 ZIKV 治疗方法方面遇到了困难，部分原因是疫苗和药物对未出生的生命和孕妇的严重后果。然而，DNA 疫苗、重组亚单位疫苗和 ZIKV 纯化灭活疫苗的体外和体内治疗效果评估为人类保护提供了希望。大量获得食品和药物管理局 (FDA) 批准的药物以及具有抗 ZIKV 活性的化合物为控制这种灾难性流行病的大量生物负担提供了宝贵的机会。一些证据表明，免疫疗法可能被证明是孕妇的制胜策略。在这里，我们综述了针对 ZIKV 感染的治疗干预的最新进展和现有知识。本文将提供基础数据和路线图，以进一步开展研究，开发新的治疗策略来遏制 ZIKV 的爆发式增长。
