Balaure Paul Cătălin, Boarca Bianca, Popescu Roxana Cristina, Savu Diana, Trusca Roxana, Vasile Bogdan Ștefan, Grumezescu Alexandru Mihai, Holban Alina Maria, Bolocan Alexandra, Andronescu Ecaterina
Department of Organic Chemistry, Faculty of Applied Chemistry and Materials Science, Politehnica University of Bucharest, Romania.
Department of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Applied Chemistry and Materials Science, Politehnica University of Bucharest, Romania.
Int J Pharm. 2017 Oct 5;531(1):35-46. doi: 10.1016/j.ijpharm.2017.08.062. Epub 2017 Aug 7.
The increasing rate of antibiotic resistant bacteria associated with nosocomial infections in severely ill patients has urged the need for new antibacterial therapies. Nanostructured materials represent emerging innovative approaches to controlled delivery of different antimicrobial drugs. Delivery systems encapsulating natural compounds with antibacterial effects, such as essential oils have shown a great potential. Herein we report the development of SiO mesoporous nanosystems loaded with eucalyptus (EUC), orange (ORA), and cinnamon (CIN) essential oils. These systems were characterized with respect to morphology (using scanning electron microscopy, SEM, and transmission electron microscopy, TEM), porosity (by BET and TEM analysis), chemical composition (by X-ray diffraction, XRD, and Fourier transform infrared spectrometry, FTIR) and loading capacity (by thermogravimetric analysis, TGA). The anti-bacterial and anti-adherence effects were tested against clinically relevant microbial species (Staphylococcus aureus ATCC 25923; Escherichia coli ATCC 25922; and Candida albicans ATCC 10231), while the biocompatibility was evaluated by in vitro tests with L929 mouse fibroblast cells.
重症患者医院感染中抗生素耐药菌的发生率不断上升，促使人们需要新的抗菌疗法。纳米结构材料代表了不同抗菌药物控释的新兴创新方法。包裹具有抗菌作用的天然化合物（如精油）的递送系统已显示出巨大潜力。在此，我们报告了负载桉叶油（EUC）、橙油（ORA）和肉桂油（CIN）的二氧化硅介孔纳米系统的开发。这些系统通过形态学（使用扫描电子显微镜（SEM）和透射电子显微镜（TEM））、孔隙率（通过BET和TEM分析）、化学成分（通过X射线衍射（XRD）和傅里叶变换红外光谱（FTIR））和负载能力（通过热重分析（TGA））进行表征。针对临床相关微生物物种（金黄色葡萄球菌ATCC 25923；大肠杆菌ATCC 25922；白色念珠菌ATCC 10231）测试了抗菌和抗粘附效果，同时通过与L929小鼠成纤维细胞的体外试验评估了生物相容性。
