Chambers James K, Saito Tsubasa, Fukushima Kenjiro, Kakuta Shigeru, Nakayama Jun, Ohno Koichi, Tsujimoto Hajime, Nakayama Hiroyuki, Uchida Kazuyuki
Laboratory of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, the University of Tokyo, 1-1-1 Yayoi, Bunkyo, Tokyo 113-8657, Japan.
Veterinary Medical Center, Graduate School of Agricultural and Life Sciences, the University of Tokyo, 1-1-1 Yayoi, Bunkyo, Tokyo 113-8657, Japan.
J Toxicol Pathol. 2017 Jul;30(3):239-243. doi: 10.1293/tox.2017-0009. Epub 2017 Apr 29.
An endoscopic examination revealed a mass in the distal esophagus of a 9-year-old intact male bulldog. Histopathologically, the mass was composed of cuboidal to columnar neoplastic epithelial cells and extended from the squamous epithelium of the esophageal mucosa, indicating that the tumor was derived from Barrett's esophagus. Moreover, highly atypical foci that exhibited a cribriform pattern and high mitotic indices were also observed. The epithelial cells on the surface of the lesion often produced mucus that was positive for Alcian blue and immunohistochemically positive for MUC5AC. The neoplastic epithelial cells were diffusely positive for cytokeratin 7 and p53, and occasionally positive for cytokeratin 20. Based on these findings, the tumor was diagnosed as an adenocarcinoma. This report describes the clinical and pathological features of a spontaneous case of adenocarcinoma of Barrett's esophagus in a dog.
内镜检查发现一只9岁未绝育雄性斗牛犬的食管远端有一个肿块。组织病理学检查显示，该肿块由立方形至柱状的肿瘤上皮细胞组成，起源于食管黏膜的鳞状上皮，提示肿瘤源自巴雷特食管。此外，还观察到具有筛状结构和高有丝分裂指数的高度非典型病灶。病变表面的上皮细胞常产生对阿尔辛蓝呈阳性反应且免疫组化对MUC5AC呈阳性反应的黏液。肿瘤上皮细胞细胞角蛋白7和p53弥漫性阳性，细胞角蛋白20偶尔阳性。基于这些发现，该肿瘤被诊断为腺癌。本报告描述了一例犬自发性巴雷特食管腺癌病例的临床和病理特征。
