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心血管疾病患者血红蛋白血卟啉的红细胞指数、红细胞形态测量指标及氧结合特性研究

Study of Erythrocyte Indices, Erythrocyte Morphometric Indicators, and Oxygen-Binding Properties of Hemoglobin Hematoporphyrin Patients with Cardiovascular Diseases.

作者信息

Revin Victor V, Ushakova Antonina A, Gromova Natalia V, Balykova Larisa A, Revina Elvira S, Stolyarova Vera V, Stolbova Tatiana A, Solomadin Ilya N, Tychkov Alexander Yu, Revina Nadezhda V, Imarova Oksana G

机构信息

Federal State-Financed Academic Institution of Higher Education "National Research Ogarev Mordovia State University", Saransk 430005, Russia.

GBUZ RM "National Hospital for War Veterans", Saransk 430005, Russia.

出版信息

Adv Hematol. 2017;2017:8964587. doi: 10.1155/2017/8964587. Epub 2017 Jul 17.

Abstract

The current study investigates the functional state of erythrocytes and indices of the oxygen-binding capacity of hemoglobin in blood samples from healthy donors and from patients with coronary artery disease and myocardial infarction before and after treatment. It has been established that, in cardiovascular diseases, erythrocyte morphology and hemoglobin oxygen-transporting disorders are observed. Standard therapy does not result in the restoration of the structure and properties of erythrocytes. The authors believe that it is necessary for future therapeutic treatment to include preparations other than cardiovascular agents to enhance the capacity of hemoglobin to transport oxygen to the tissues.

摘要

本研究调查了健康供体以及冠心病和心肌梗死患者治疗前后血液样本中红细胞的功能状态和血红蛋白的氧结合能力指标。已经确定,在心血管疾病中,会观察到红细胞形态和血红蛋白氧运输紊乱。标准治疗并不能恢复红细胞的结构和特性。作者认为,未来的治疗方案有必要纳入心血管药物以外的制剂,以提高血红蛋白向组织输送氧气的能力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a73e/5535697/5de38befbf26/AH2017-8964587.001.jpg

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