线粒体未折叠蛋白反应作为一种非癌基因成瘾，以支持癌症发生及其他过程中细胞对压力的适应。
The Mitochondrial Unfolded Protein Response as a Non-Oncogene Addiction to Support Adaptation to Stress during Transformation in Cancer and Beyond.
作者信息
Kenny Timothy C, Manfredi Giovanni, Germain Doris
机构信息
Department of Medicine, Division of Hematology/Oncology, Icahn School of Medicine at Mount Sinai, Tisch Cancer Institute, New York, NY, Unites States.
Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY, Unites States.
出版信息
Front Oncol. 2017 Jul 26;7:159. doi: 10.3389/fonc.2017.00159. eCollection 2017.
Upon accumulation of misfolded proteins in the mitochondria, the mitochondrial unfolded protein response (UPR) is activated. This review focuses on the role of this response in cancer. We discuss evidence that during transformation, the UPR may play an essential role in the maintenance of the integrity of the mitochondria in the face of increased oxidative stress. However, the role of the UPR in other diseases is also emerging and is therefore also briefly discussed.
当线粒体中错误折叠的蛋白质积累时，线粒体未折叠蛋白反应（UPR）被激活。本综述聚焦于这种反应在癌症中的作用。我们讨论了相关证据，即在细胞转化过程中，面对增加的氧化应激，UPR可能在维持线粒体完整性方面发挥重要作用。然而，UPR在其他疾病中的作用也正在显现，因此也将简要讨论。
Zotero 插件