• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

线粒体未折叠蛋白反应作为一种非癌基因成瘾，以支持癌症发生及其他过程中细胞对压力的适应。

The Mitochondrial Unfolded Protein Response as a Non-Oncogene Addiction to Support Adaptation to Stress during Transformation in Cancer and Beyond.

作者信息

Kenny Timothy C, Manfredi Giovanni, Germain Doris

机构信息

Department of Medicine, Division of Hematology/Oncology, Icahn School of Medicine at Mount Sinai, Tisch Cancer Institute, New York, NY, Unites States.

Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY, Unites States.

出版信息

Front Oncol. 2017 Jul 26;7:159. doi: 10.3389/fonc.2017.00159. eCollection 2017.

DOI:10.3389/fonc.2017.00159
PMID:28798902
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5526845/
Abstract

Upon accumulation of misfolded proteins in the mitochondria, the mitochondrial unfolded protein response (UPR) is activated. This review focuses on the role of this response in cancer. We discuss evidence that during transformation, the UPR may play an essential role in the maintenance of the integrity of the mitochondria in the face of increased oxidative stress. However, the role of the UPR in other diseases is also emerging and is therefore also briefly discussed.

摘要

当线粒体中错误折叠的蛋白质积累时，线粒体未折叠蛋白反应（UPR）被激活。本综述聚焦于这种反应在癌症中的作用。我们讨论了相关证据，即在细胞转化过程中，面对增加的氧化应激，UPR可能在维持线粒体完整性方面发挥重要作用。然而，UPR在其他疾病中的作用也正在显现，因此也将简要讨论。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/702c/5526845/1f8dd2a49b77/fonc-07-00159-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/702c/5526845/1f8dd2a49b77/fonc-07-00159-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/702c/5526845/1f8dd2a49b77/fonc-07-00159-g001.jpg

相似文献

1
The Mitochondrial Unfolded Protein Response as a Non-Oncogene Addiction to Support Adaptation to Stress during Transformation in Cancer and Beyond.线粒体未折叠蛋白反应作为一种非癌基因成瘾，以支持癌症发生及其他过程中细胞对压力的适应。
Front Oncol. 2017 Jul 26;7:159. doi: 10.3389/fonc.2017.00159. eCollection 2017.
2
Mitochondria Retrograde Signaling and the UPR mt: Where Are We in Mammals?线粒体逆行信号传导与线粒体未折叠蛋白反应：在哺乳动物中我们进展到哪一步了？
Int J Mol Sci. 2015 Aug 6;16(8):18224-51. doi: 10.3390/ijms160818224.
3
The mitochondrial unfolded protein response (UPR): shielding against toxicity to mitochondria in cancer.线粒体未折叠蛋白反应（UPR）：在癌症中抵御线粒体毒性。
J Hematol Oncol. 2022 Jul 21;15(1):98. doi: 10.1186/s13045-022-01317-0.
4
Sensing the Stress: A Role for the UPR and UPR in the Quality Control of Mitochondria.感知压力：未折叠蛋白反应在内质网及线粒体质量控制中的作用
Front Cell Dev Biol. 2018 Mar 28;6:31. doi: 10.3389/fcell.2018.00031. eCollection 2018.
5
Dysregulation of the Mitochondrial Unfolded Protein Response Induces Non-Apoptotic Dopaminergic Neurodegeneration in Models of Parkinson's Disease.线粒体未折叠蛋白反应失调在帕金森病模型中诱导非凋亡性多巴胺能神经变性。
J Neurosci. 2017 Nov 15;37(46):11085-11100. doi: 10.1523/JNEUROSCI.1294-17.2017. Epub 2017 Oct 13.
6
From discovery of the CHOP axis and targeting ClpP to the identification of additional axes of the UPRmt driven by the estrogen receptor and SIRT3.从发现 CHOP 轴并靶向 ClpP 到鉴定受雌激素受体和 SIRT3 驱动的 UPRmt 的其他轴。
J Bioenerg Biomembr. 2017 Aug;49(4):297-305. doi: 10.1007/s10863-017-9722-z. Epub 2017 Aug 10.
7
Sirtuins and the Estrogen Receptor as Regulators of the Mammalian Mitochondrial UPR in Cancer and Aging.作为癌症与衰老中哺乳动物线粒体未折叠蛋白反应调节因子的去乙酰化酶家族与雌激素受体
Adv Cancer Res. 2016;130:211-56. doi: 10.1016/bs.acr.2016.01.004. Epub 2016 Mar 2.
8
Sphingosine Kinase Activates the Mitochondrial Unfolded Protein Response and Is Targeted to Mitochondria by Stress.鞘氨醇激酶通过应激激活线粒体未折叠蛋白反应，并通过应激靶向到线粒体。
Cell Rep. 2018 Sep 11;24(11):2932-2945.e4. doi: 10.1016/j.celrep.2018.08.037.
9
Are the estrogen receptor and SIRT3 axes of the mitochondrial UPR key regulators of breast cancer sub-type determination according to age?根据年龄，线粒体未折叠蛋白反应的雌激素受体和SIRT3轴是乳腺癌亚型决定的关键调节因子吗？
Aging Cancer. 2021 Sep;2(3):75-81. doi: 10.1002/aac2.12035. Epub 2021 Aug 6.
10
Cross talk between SOD1 and the mitochondrial UPR in cancer and neurodegeneration.SOD1 与线粒体 UPR 在癌症和神经退行性变中的对话。
Mol Cell Neurosci. 2019 Jul;98:12-18. doi: 10.1016/j.mcn.2019.04.003. Epub 2019 Apr 24.

引用本文的文献

1
Targeting mitochondrial proteases CLPP and LONP1 via disruption of mitochondrial redox homeostasis induces proteotoxic stress and suppresses tumor progression.通过破坏线粒体氧化还原稳态靶向线粒体蛋白酶CLPP和LONP1可诱导蛋白毒性应激并抑制肿瘤进展。
Cell Commun Signal. 2025 Sep 3;23(1):393. doi: 10.1186/s12964-025-02127-w.
2
ULP-2 SUMO protease regulates UPR and mitochondrial homeostasis in Caenorhabditis elegans.ULP-2 SUMO 蛋白酶调节秀丽隐杆线虫中的 UPR 和线粒体稳态。
Free Radic Biol Med. 2024 Mar;214:19-27. doi: 10.1016/j.freeradbiomed.2024.01.050. Epub 2024 Jan 30.
3
Recent progress in understanding mitokines as diagnostic and therapeutic targets in hepatocellular carcinoma.

本文引用的文献

1
The UPR: Sensor and Coordinator of Organismal Homeostasis.未折叠蛋白反应：机体稳态的传感器和协调器。
Mol Cell. 2017 Jun 15;66(6):761-771. doi: 10.1016/j.molcel.2017.05.031.
2
Multi-omics analysis identifies ATF4 as a key regulator of the mitochondrial stress response in mammals.多组学分析确定ATF4是哺乳动物线粒体应激反应的关键调节因子。
J Cell Biol. 2017 Jul 3;216(7):2027-2045. doi: 10.1083/jcb.201702058. Epub 2017 May 31.
3
Selected mitochondrial DNA landscapes activate the SIRT3 axis of the UPR to promote metastasis.选定的线粒体DNA景观激活未折叠蛋白反应的SIRT3轴以促进转移。
将线粒体因子作为肝细胞癌诊断和治疗靶点的最新进展。
World J Clin Cases. 2023 Aug 16;11(23):5416-5429. doi: 10.12998/wjcc.v11.i23.5416.
4
The mitochondrial unfolded protein response (UPR): shielding against toxicity to mitochondria in cancer.线粒体未折叠蛋白反应（UPR）：在癌症中抵御线粒体毒性。
J Hematol Oncol. 2022 Jul 21;15(1):98. doi: 10.1186/s13045-022-01317-0.
5
A mitochondrial unfolded protein response inhibitor suppresses prostate cancer growth in mice via HSP60.一种线粒体未折叠蛋白反应抑制剂通过 HSP60 抑制小鼠前列腺癌生长。
J Clin Invest. 2022 Jul 1;132(13). doi: 10.1172/JCI149906.
6
Are the estrogen receptor and SIRT3 axes of the mitochondrial UPR key regulators of breast cancer sub-type determination according to age?根据年龄，线粒体未折叠蛋白反应的雌激素受体和SIRT3轴是乳腺癌亚型决定的关键调节因子吗？
Aging Cancer. 2021 Sep;2(3):75-81. doi: 10.1002/aac2.12035. Epub 2021 Aug 6.
7
Targeting Mitochondrial Protein Expression as a Future Approach for Cancer Therapy.靶向线粒体蛋白表达作为癌症治疗的未来方法。
Front Oncol. 2021 Nov 23;11:797265. doi: 10.3389/fonc.2021.797265. eCollection 2021.
8
Targeting the mitochondrial unfolded protein response in cancer: opportunities and challenges.靶向肿瘤线粒体未折叠蛋白反应：机遇与挑战。
Trends Cancer. 2021 Dec;7(12):1050-1053. doi: 10.1016/j.trecan.2021.08.008. Epub 2021 Sep 24.
9
Mitochondrial Metabolic Signatures in Hepatocellular Carcinoma.肝细胞癌中的线粒体代谢特征。
Cells. 2021 Jul 27;10(8):1901. doi: 10.3390/cells10081901.
10
SIRT3-mediated mitochondrial unfolded protein response weakens breast cancer sensitivity to cisplatin.SIRT3介导的线粒体未折叠蛋白反应减弱乳腺癌对顺铂的敏感性。
Genes Genomics. 2021 Dec;43(12):1433-1444. doi: 10.1007/s13258-021-01145-5. Epub 2021 Aug 2.
Oncogene. 2017 Aug;36(31):4393-4404. doi: 10.1038/onc.2017.52. Epub 2017 Apr 3.
4
Cytosolic proteostasis through importing of misfolded proteins into mitochondria.通过将错误折叠的蛋白质导入线粒体实现胞质蛋白质稳态。
Nature. 2017 Mar 16;543(7645):443-446. doi: 10.1038/nature21695. Epub 2017 Mar 1.
5
Sex specific activation of the ERα axis of the mitochondrial UPR (UPRmt) in the G93A-SOD1 mouse model of familial ALS.在家族性肌萎缩侧索硬化症的G93A-SOD1小鼠模型中，线粒体未折叠蛋白反应（UPRmt）的雌激素受体α（ERα）轴的性别特异性激活。
Hum Mol Genet. 2017 Apr 1;26(7):1318-1327. doi: 10.1093/hmg/ddx049.
6
Systemic insulin sensitivity is regulated by GPS2 inhibition of AKT ubiquitination and activation in adipose tissue.全身胰岛素敏感性受 GPS2 抑制脂肪组织中 AKT 泛素化和激活的调节。
Mol Metab. 2016 Oct 31;6(1):125-137. doi: 10.1016/j.molmet.2016.10.007. eCollection 2017 Jan.
7
Inhibition of Ubc13-mediated Ubiquitination by GPS2 Regulates Multiple Stages of B Cell Development.GPS2对Ubc13介导的泛素化的抑制作用调控B细胞发育的多个阶段。
J Biol Chem. 2017 Feb 17;292(7):2754-2772. doi: 10.1074/jbc.M116.755132. Epub 2016 Dec 30.
8
Transgenic Expression of the Mitochondrial Chaperone TNFR-associated Protein 1 (TRAP1) Accelerates Prostate Cancer Development.线粒体伴侣肿瘤坏死因子受体相关蛋白1（TRAP1）的转基因表达加速前列腺癌发展。
J Biol Chem. 2016 Nov 25;291(48):25247-25254. doi: 10.1074/jbc.M116.745950. Epub 2016 Oct 17.
9
The Transcription Factor ATF5 Mediates a Mammalian Mitochondrial UPR.转录因子ATF5介导哺乳动物线粒体未折叠蛋白反应。
Curr Biol. 2016 Aug 8;26(15):2037-2043. doi: 10.1016/j.cub.2016.06.002. Epub 2016 Jul 14.
10
Homeostatic Responses Regulate Selfish Mitochondrial Genome Dynamics in C. elegans.稳态反应调节秀丽隐杆线虫中自私线粒体基因组的动态变化。
Cell Metab. 2016 Jul 12;24(1):91-103. doi: 10.1016/j.cmet.2016.06.008.