Immunoregulation Research Center, Shahed University, Tehran, Iran.
Medical Students Research Committee, Shahed University, Tehran, Iran.
Neurol Sci. 2017 Nov;38(11):1941-1951. doi: 10.1007/s10072-017-3080-9. Epub 2017 Aug 10.
Studies have shown an increase in the incidence of MS in Iran. The aim of our study was to evaluate the relationship between environmental exposure and MS in Iran. This case-control study was conducted on 660 MS patients and 421 controls. Many environmental factors are compared between the two groups. Our findings demonstrated that prematurity ([OR = 4.99 (95% CI 1.34-18.68), P = 0.017]), history of measles and mumps ([OR = 1.60 (95% CI 1.05-2.45), P = 0.029; OR = 1.85 (95% CI 1.22-2.78), P = 0.003, respectively]), breast feeding [OR = 2.90 (95% CI 1.49-5.65), P = 0.002], head trauma in childhood ([OR = 8.21 (95% CI 1.56-43.06), P = 0.013]), vaccination in adulthood ([OR = 4.57 (95% CI 1.14-18.41), P = 0.032, respectively]), migraine ([OR = 3.50 (95% CI 1.61-7.59), P = 0.002]), family history of MS, IBD, migraine, and collagen vascular diseases ([OR = 2.73 (95% CI 1.56-4.78), P < 0.001], [OR = 3.14 (95% CI 1.460-6.78), P = 0.004; OR = 3.18 (95% CI 1.83-5.53), P < 0.001; OR = 1.81 (95% CI 1.03-3.20), P = 0.040, respectively]), stressful events ([OR = 32.57 (95% CI 17.21-61.64), P < 0.001]), and microwave exposure ([OR = 3.55 (95% CI 2.24-5.63), P ≤0.001]) were more in the MS group. Sun exposure ([OR = 0.09 (95% CI 0.02-0.38), P = 0.001]), dairy and calcium consumption ([OR = 0.44 (95% CI 0.27-0.71), P = 0.001]), diabetes mellitus ([OR = 0.11 (95% CI 0.01-00.99), P = 0.049], and complete vaccination during childhood appeared to decreased MS risk. Our results investigated many risk factors and protective factors in Iran.
研究表明，多发性硬化症（MS）在伊朗的发病率有所增加。本研究旨在评估伊朗环境暴露与 MS 之间的关系。这项病例对照研究共纳入了 660 名 MS 患者和 421 名对照。比较了两组之间的许多环境因素。我们的研究结果表明，早产（[比值比（OR）=4.99（95%置信区间（CI）1.34-18.68），P=0.017]）、麻疹和风疹史（[OR=1.60（95%CI 1.05-2.45），P=0.029；OR=1.85（95%CI 1.22-2.78），P=0.003）]）、母乳喂养（[OR=2.90（95%CI 1.49-5.65），P=0.002）]）、儿童时期头部外伤（[OR=8.21（95%CI 1.56-43.06），P=0.013）]）、成年期接种疫苗（[OR=4.57（95%CI 1.14-18.41），P=0.032）]）、偏头痛（[OR=3.50（95%CI 1.61-7.59），P=0.002）]）、MS、炎症性肠病（IBD）、偏头痛和胶原血管疾病家族史（[OR=2.73（95%CI 1.56-4.78），P<0.001]）、[OR=3.14（95%CI 1.460-6.78），P=0.004；OR=3.18（95%CI 1.83-5.53），P<0.001）；OR=1.81（95%CI 1.03-3.20），P=0.040）]）、压力事件（[OR=32.57（95%CI 17.21-61.64），P<0.001）]）和微波暴露（[OR=3.55（95%CI 2.24-5.63），P ≤0.001）]）在 MS 组中更为常见。阳光照射（[OR=0.09（95%CI 0.02-0.38），P=0.001）]）、奶制品和钙的摄入（[OR=0.44（95%CI 0.27-0.71），P=0.001）]）、糖尿病（[OR=0.11（95%CI 0.01-0.99），P=0.049）]）和儿童期完成疫苗接种似乎降低了 MS 的风险。我们的研究结果调查了伊朗的许多风险因素和保护因素。
