Eftekharian Mohammad Mahdi, Ghannad Masoud Sabouri, Taheri Mohammad, Roshanaei Ghodratollah, Mazdeh Mehrdokht, Musavi Mehrnoosh, Hormoz Mona Bahmani
Faculty of Paramedicine, Research Center for Molecular Medicine, Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, Iran.
Research Center for Molecular Medicine, Department of Microbiology, Faculty of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.
Hum Antibodies. 2016 Jun 8;24(1-2):17-23. doi: 10.3233/HAB-150289.
Multiple sclerosis (MS) is a complicated disease which occurs due to relationship between genes and environmental factors that causes tissue damage by autoimmune mechanisms.We investigated and illustrated the hypotheses correlated to the evidence of several putative environmental risk factors for MS onset and progression in this part of Iran.
Univariate logistic regression was used to detect the effects of environmental factors on the risk of MS. Data were analyzed using SPSS version 16.
The childhood history of patients with rubella, measles and chickenpox increased the risk of MS significantly. Moreover, low consumption of dairy products, avoidance of seafood consumption, cigarette smoking and exposure to tobacco smoke, stress, anxiety disorders, depress and disturbing thoughts, negative and disturbing thoughts, developing a sudden shock upon hearing bad news, having obsessive-compulsive and being depressed increased the risk of MS significantly.
The results of the current research partially solved the puzzling question of complex interplay between environmental factors and MS disease in this part of Iran. Incorporating these factors enables more powerful and accurate detection of novel risk factors with diagnostic and prognostic methods.
多发性硬化症（MS）是一种复杂的疾病，它因基因与环境因素之间的相互关系而发生，通过自身免疫机制导致组织损伤。我们在伊朗的这一地区调查并阐述了与MS发病和进展的几种假定环境危险因素证据相关的假说。
采用单因素逻辑回归分析环境因素对MS风险的影响。数据使用SPSS 16版进行分析。
患风疹、麻疹和水痘的儿童病史会显著增加MS风险。此外，乳制品摄入量低、避免食用海鲜、吸烟和接触烟草烟雾、压力、焦虑症、抑郁和困扰性想法、消极和困扰性想法、听到坏消息时受到突然惊吓、患有强迫症和抑郁症会显著增加MS风险。
当前研究结果部分解决了伊朗这一地区环境因素与MS疾病之间复杂相互作用的令人困惑的问题。纳入这些因素能够通过诊断和预后方法更有力、准确地检测出新的危险因素。
