Cohort study Center, Shahrekord University of Medical Sciences, Iran.
Department of Epidemiology, School of Public Health, Arak University of Medical Sciences, Iran.
Mult Scler Relat Disord. 2018 Feb;20:164-168. doi: 10.1016/j.msard.2018.01.019. Epub 2018 Mar 20.
Increase of MS prevalence in females compared to males, especially in reproductive age, highlights the important role of reproductive factors in MS pathology.
We examined the association between females' reproductive age-related factors and MS risk.
A case-control study including 399 cases and 541 controls was carried out. The adjusted associations between MS risk and reproductive variables including age at menarche, oral contraceptive pills (OCPs) use history, OCP usage duration and age at first use, history of assisted reproductive technologies (ARTs) use, parity history, age at first childbirth and the number of parities, abortion and exclusive breast feeding > 2 months were assessed.
We found protective relationships between MS and older age at menarche (OR = 0.90 {95% CI = 0.82-0.98}), ART use history (OR = 0.45 {95% CI = 0.21-0.99}), older maternal age at first childbirth (OR = 0.94{95% CI = 0.89 - 0.99}) and higher number of parities(OR = 0.61 {95% CI = 0.49 - 0.75), whereas using OCPs was associated with higher risk of developing MS (OR = 1.80 {95% CI = 1.35-2.41}).
Links were noted between a number of reproductive factors and risk of MS.
与男性相比，女性多发性硬化症（MS）的患病率增加，尤其是在生育年龄，这突出了生殖因素在 MS 病理中的重要作用。
我们研究了女性生殖年龄相关因素与 MS 风险之间的关联。
进行了一项病例对照研究，纳入 399 例病例和 541 例对照。评估了 MS 风险与生殖变量（包括初潮年龄、口服避孕药（OCPs）使用史、OCP 使用持续时间和首次使用年龄、辅助生殖技术（ARTs）使用史、生育史、首次分娩年龄和产次、流产和纯母乳喂养>2 个月）之间的调整关联。
我们发现初潮年龄较大（OR=0.90，95%CI=0.82-0.98）、有 ART 使用史（OR=0.45，95%CI=0.21-0.99）、初产妇年龄较大（OR=0.94，95%CI=0.89-0.99）和产次较高（OR=0.61，95%CI=0.49-0.75）与 MS 呈保护关系，而使用 OCP 与 MS 发病风险增加相关（OR=1.80，95%CI=1.35-2.41）。
多项生殖因素与 MS 风险之间存在关联。
