Shirbeigi Laila, Dalfardi Behnam, Abolhassanzadeh Zohreh, Nejatbakhsh Fatemeh
Department of Iranian Traditional Medicine, School of Traditional Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran.
Curr Drug Metab. 2018;19(5):414-423. doi: 10.2174/1389200218666170810170124.
Dementia is a chronic neurodegenerative disease causing progressive and gradual impairment of different brain's cognitive functions. The prevalence of dementia is about 3 to 7% in different parts of the world.
The aim of this study was to determine the etiologies of dementia according to the Traditional Persian Medicine scientists' viewpoint and introduce their recommended herbal remedies for this disease.
The authors explored six main Traditional Persian Medicine textbooks for the disease of dementia, its etiologies and related recommended herbal treatments. Two main keywords of "Lisarghes" and" Nesyan" were searched for this purpose. Medical databases, including PubMed, Scopus, Google Scholar, and Science Direct were searched for related articles published between 1966 and 2016 to review the pharmacological components and active ingredients of suggested herbal medicines.
According to the Traditional Persian Medicine, dementia is resulted from brain dystemperament, a condition caused by cold and moist or cold and dry tempers. To treat this disease, Traditional Persian scientists recommended various herbal remedies. Current studies have demonstrated that some of these medicinal plants have beneficial effects for the aforementioned disease, including acetyl cholinesterase inhibitory function, neuroprotective effects, and memory enhancing role.
The Traditional Persian Medicine literature suggested different herbal remedies for treating dementia. Modern studies support the usefulness of some of these medicines. However, the effect of a large number of these remedies has remained unexamined, a matter which needs to be investigated in future researches.
痴呆是一种慢性神经退行性疾病，会导致大脑不同认知功能逐渐进行性受损。痴呆在世界不同地区的患病率约为3%至7%。
本研究旨在根据传统波斯医学科学家的观点确定痴呆的病因，并介绍他们针对该疾病推荐的草药疗法。
作者查阅了六本主要的传统波斯医学教科书，以了解痴呆疾病、其病因及相关推荐草药治疗方法。为此搜索了两个主要关键词“Lisarghes”和“Nesyan”。检索了包括PubMed、Scopus、谷歌学术和科学Direct在内的医学数据库，以查找1966年至2016年间发表的相关文章，以回顾所建议草药的药理成分和活性成分。
根据传统波斯医学，痴呆是由脑气质失调引起的，这种情况是由寒湿或寒燥的体质导致的。为治疗这种疾病，传统波斯科学家推荐了各种草药疗法。目前的研究表明，其中一些药用植物对上述疾病有有益作用，包括乙酰胆碱酯酶抑制功能、神经保护作用和增强记忆的作用。
传统波斯医学文献提出了不同的草药疗法来治疗痴呆。现代研究支持其中一些药物的有效性。然而，这些疗法中大量药物的效果仍未得到检验，这一问题需要在未来的研究中进行调查。
