Department of Biosciences, Biotechnologies and Biopharmaceutics, University of Bari, Via Orabona, 4, 70126, Bari, Italy.
Department of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy.
Cytokine Growth Factor Rev. 2017 Oct;37:67-79. doi: 10.1016/j.cytogfr.2017.07.005. Epub 2017 Aug 1.
Suppressor of cytokine signaling proteins (SOCS) are a family of intracellular cytokine inducible proteins, consisting of eight members. They are involved in the complex control of the inflammatory response through their actions on various signaling pathways, including the JAK/STAT and NF-κB pathways. A series of studies has shown that SOCS proteins are involved in the regulation and progression of immune responses in microglia cells. The accumulated data suggest that modulation of SOCS expression could be a target for drug development aimed at controlling inflammation in the brain. This review focuses on the current understanding of SOCS proteins involvement in inflammation-based neurodegenerative diseases and their role as therapeutic targets in future approaches.
抑制细胞因子信号转导蛋白（SOCS）是细胞内细胞因子诱导蛋白家族的一员，由八个成员组成。它们通过对各种信号通路（包括 JAK/STAT 和 NF-κB 通路）的作用，参与炎症反应的复杂调控。一系列研究表明，SOCS 蛋白参与小胶质细胞免疫反应的调节和进展。积累的数据表明，调节 SOCS 的表达可能是开发旨在控制大脑炎症的药物的目标。本综述重点介绍了 SOCS 蛋白在基于炎症的神经退行性疾病中的作用及其作为未来治疗方法中治疗靶点的作用。
