Martinez-Martin Pablo, Rodriguez-Blazquez Carmen, Forjaz Maria João, Kurtis Monica M, Skorvanek Matej
National Center of Epidemiology and CIBERNED, Institute of Health Carlos III, Madrid, Spain.
National Center of Epidemiology and CIBERNED, Institute of Health Carlos III, Madrid, Spain.
Int Rev Neurobiol. 2017;133:291-345. doi: 10.1016/bs.irn.2017.04.001. Epub 2017 Jun 1.
Nonmotor symptoms constitute a prominent part of Parkinson's disease manifestations. They are present since the first phases of the disease, increase their number and severity with disease progression, and importantly impact on patients' health and quality of life, caregivers' burden, and social resources. Research on Parkinson's disease has traditionally focused on the motor aspects of the disease, but an increasing interest in the nonmotor manifestations has risen in the past decade. The availability of assessment instruments for detecting and measuring these symptoms has allowed understanding of their importance and course over time, as well as estimation of therapeutic effects on them. In this chapter, a review of the basic characteristics of nonmotor symptom assessments used in clinical practice and research are presented.
非运动症状是帕金森病临床表现的一个突出部分。它们在疾病的最初阶段就已出现，随着疾病进展其数量和严重程度增加，并且对患者的健康和生活质量、照料者的负担以及社会资源产生重要影响。传统上，帕金森病的研究主要集中在疾病的运动方面，但在过去十年中，人们对非运动表现的兴趣日益增加。用于检测和测量这些症状的评估工具的出现，使人们能够了解它们的重要性和随时间的变化过程，以及评估对它们的治疗效果。在本章中，将对临床实践和研究中使用的非运动症状评估的基本特征进行综述。
