Katunina Elena, Titova Nataliya
Federal State Budgetary Educational Institution of Higher Education, "N.I. Pirogov Russian National Research Medical University" of the Ministry of Healthcare of the Russian Federation, Moscow, Russia.
Federal State Budgetary Educational Institution of Higher Education, "N.I. Pirogov Russian National Research Medical University" of the Ministry of Healthcare of the Russian Federation, Moscow, Russia.
Int Rev Neurobiol. 2017;133:91-110. doi: 10.1016/bs.irn.2017.05.012. Epub 2017 Jun 27.
Nonmotor symptoms (NMS) of Parkinson's disease (PD) were recognized by James Parkinson himself and are now considered to be an integral part of PD. While clinical assessment had focused on prevalence and severity of individual NMS such as dementia and depression, work in the last decade has concentrated on global or holistic assessment of NMS using validated tools such as the NMS questionnaire and NMS scale. These studies from cohorts of varying sizes have allowed comparison of NMS across different disease stages, duration, age, and ethnicity in PD. The data also allow exploration of the concept of the nonlinear relationship of NMS to disease duration of PD and motor stages as well as nonmotor subtypes of PD. In this chapter, these aspects of epidemiological studies of NMS in PD cohorts are described.
帕金森病（PD）的非运动症状（NMS）由詹姆斯·帕金森本人首次发现，如今已被视为帕金森病不可或缺的一部分。虽然临床评估一直聚焦于诸如痴呆和抑郁等个体非运动症状的患病率和严重程度，但过去十年的研究集中在使用如非运动症状问卷和非运动症状量表等经过验证的工具对非运动症状进行整体或全面评估。这些来自不同规模队列的研究使得在帕金森病中能够比较不同疾病阶段、病程、年龄和种族的非运动症状。这些数据还允许探讨非运动症状与帕金森病病程、运动阶段以及帕金森病非运动亚型之间非线性关系的概念。在本章中，将描述帕金森病队列中非运动症状流行病学研究的这些方面。
