阿替洛尔、索他洛尔和拉贝洛尔对人体肌肉血流影响的比较。
Comparison of the effects of atenolol, sotalol and labetalol on muscle blood flow in man.
作者信息
Raman G V, Mwongera F M, Warren D J
出版信息
Postgrad Med J. 1986 Sep;62(731):841-4. doi: 10.1136/pgmj.62.731.841.
Abstract
A double-blind study of the effect of three beta-adrenoceptor blocking drugs (beta-blockers) on exercise muscle blood flow (MBF) in 14 normotensive volunteers was carried out. MBF was measured by the xenon-133 clearance technique. MBF was not altered by placebo, sotalol or labetalol. Atenolol significantly reduced MBF compared with placebo, sotalol and labetalol. We conclude that sotalol and labetalol may be more useful than conventional beta-blockers for treatment of hypertension or angina in association with peripheral vascular disease.
摘要
对14名血压正常的志愿者进行了一项双盲研究，以观察三种β-肾上腺素能受体阻滞剂（β-阻滞剂）对运动肌肉血流（MBF）的影响。MBF采用氙-133清除技术进行测量。安慰剂、索他洛尔或拉贝洛尔对MBF无影响。与安慰剂、索他洛尔和拉贝洛尔相比，阿替洛尔显著降低了MBF。我们得出结论，对于合并外周血管疾病的高血压或心绞痛患者，索他洛尔和拉贝洛尔可能比传统β-阻滞剂更有用。
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