McSorley P D, Warren D J
Br Med J. 1978 Dec 9;2(6152):1598-600. doi: 10.1136/bmj.2.6152.1598.
The effects of single doses of propranolol and metoprolol on skin temperature and skin and muscle blood flow were compared in 10 normal subjects and four patients with essential hypertension. In normal subjects the mean skin temperature fell by 1.30 +/- 0.62 degrees C 90 minutes after 80 mg propranolol and 0.15 +/- 0.05 degrees C after 100 mg metoprolol. Skin blood flow and resting muscle blood flow were not affected by metoprolol but fell significantly after propranolol. Both drugs reduced post-exercise muscle hyperaemia, propranolol by more than metoprolol. Similar changes were seen in the hypertensive patients. Propranolol should be used with care in patients with known vascular disease.
在10名正常受试者和4名原发性高血压患者中比较了单次剂量普萘洛尔和美托洛尔对皮肤温度以及皮肤和肌肉血流的影响。在正常受试者中，80毫克普萘洛尔给药90分钟后平均皮肤温度下降1.30±0.62摄氏度，100毫克美托洛尔给药后下降0.15±0.05摄氏度。美托洛尔对皮肤血流和静息肌肉血流无影响，但普萘洛尔给药后显著下降。两种药物均能减轻运动后肌肉充血，普萘洛尔的作用比美托洛尔更明显。高血压患者也出现了类似变化。已知有血管疾病的患者应谨慎使用普萘洛尔。
