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不同类型红肉、禽肉和鱼肉的摄入量与男性和女性结直肠癌发病情况:马尔默饮食与癌症研究结果

Intake of different types of red meat, poultry, and fish and incident colorectal cancer in women and men: results from the Malmö Diet and Cancer Study.

作者信息

Vulcan Alexandra, Manjer Jonas, Ericson Ulrika, Ohlsson Bodil

机构信息

Division of Internal Medicine, Department of Clinical Science, Lund University, Skåne University Hospital, Malmö, Sweden.

Division of Surgery, Department of Clinical Science, Lund University, Skåne University Hospital, Malmö, Sweden.

出版信息

Food Nutr Res. 2017 Jul 18;61(1):1341810. doi: 10.1080/16546628.2017.1341810. eCollection 2017.

Abstract

: Colorectal cancer (CRC) is considered one of the most common forms of cancer in the Western world. High intake of red and processed meat is considered to increase CRC development. : This study examined associations between intake of red meats, poultry, and fish and incident CRC, and if weight status modifies the associations. : In the Malmö Diet and Cancer Study, dietary data was collected through a modified diet history method. Via the Swedish Cancer Registry, 728 cases of CRC were identified during 428 924 person-years of follow-up of 16 944 women and 10 987 men. : Beef intake was inversely associated with colon cancer. However, in men high intake of beef was associated with increased risk of rectal cancer. High intake of pork was associated with increased incidence of CRC, and colon cancer. Processed meat was associated with increased risk of CRC in men. Fish intake was inversely associated with risk of rectal cancer. No significant interactions were found between different types of meat and weight status. : Findings suggest that associations between meat intake and CRC differ depending on meat type, sex, and tumor location in the bowel. Weight status did not modify observed associations.

摘要

结直肠癌(CRC)被认为是西方世界最常见的癌症形式之一。大量摄入红肉和加工肉类被认为会增加结直肠癌的发病风险。本研究调查了红肉、家禽和鱼类的摄入量与结直肠癌发病之间的关联,以及体重状况是否会改变这种关联。在马尔默饮食与癌症研究中,通过改良的饮食史方法收集饮食数据。通过瑞典癌症登记处,在对16944名女性和10987名男性进行的428924人年的随访中,确定了728例结直肠癌病例。牛肉摄入量与结肠癌呈负相关。然而,在男性中,大量摄入牛肉与直肠癌风险增加有关。大量摄入猪肉与结直肠癌和结肠癌的发病率增加有关。加工肉类与男性结直肠癌风险增加有关。鱼类摄入量与直肠癌风险呈负相关。在不同类型的肉类和体重状况之间未发现显著的相互作用。研究结果表明,肉类摄入量与结直肠癌之间的关联因肉类类型、性别和肠道肿瘤位置而异。体重状况并未改变观察到的关联。

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