通过流式细胞术评估全血中的血小板功能。

Assessment of Platelet Function in Whole Blood by Flow Cytometry.

作者信息

Pasalic Leonardo

机构信息

Deparments of Clinical and Laboratory Haematology, Institute of Clinical Pathology and Medical Research, Westmead Hospital, Westmead, NSW, 2145, Australia.

Sydney Centres for Thrombosis and Haemostasis, Westmead, NSW, Australia.

出版信息

Methods Mol Biol. 2017;1646:349-367. doi: 10.1007/978-1-4939-7196-1_27.

DOI:10.1007/978-1-4939-7196-1_27

PMID:28804841

Abstract

Evaluation of platelet function is important for understanding the physiology of hemostasis and thrombosis and is utilized in clinical practice to diagnose inherited and acquired platelet bleeding disorders. Flow cytometry is a powerful tool for rapid evaluation of multiple functional properties of large number of platelets in whole blood and offers many advantages over other traditional methods. Attention to pre-analytical factors is required to ensure biologically valid and robust results.

摘要

血小板功能评估对于理解止血和血栓形成的生理学很重要，并且在临床实践中用于诊断遗传性和获得性血小板出血性疾病。流式细胞术是快速评估全血中大量血小板多种功能特性的强大工具，与其他传统方法相比具有许多优势。需要注意分析前因素以确保获得生物学上有效且可靠的结果。