Greenhalgh Trisha, Ovseiko Pavel V, Fahy Nick, Shaw Sara, Kerr Polly, Rushforth Alexander D, Channon Keith M, Kiparoglou Vasiliki
Nuffield Department of Primary Care Health Sciences, University of Oxford, Radcliffe Primary Care Building, Woodstock Rd, Oxford, OX2 6GG, United Kingdom.
Radcliffe Department of Medicine, University of Oxford, John Radcliffe Hospital, Oxford, OX3 9DU, United Kingdom.
Health Res Policy Syst. 2017 Aug 14;15(1):70. doi: 10.1186/s12961-017-0237-1.
Biomedical Research Centres (BRCs) are partnerships between healthcare organisations and universities in England. Their mission is to generate novel treatments, technologies, diagnostics and other interventions that increase the country's international competitiveness, to rapidly translate these innovations into benefits for patients, and to improve efficiency and reduce waste in healthcare. As NIHR Oxford BRC (Oxford BRC) enters its third 5-year funding period, we seek to (1) apply the evidence base on how best to support the various partnerships in this large, multi-stakeholder research system and (2) research how these partnerships play out in a new, ambitious programme of translational research.
Organisational case study, informed by the principles of action research. A cross-cutting theme, 'Partnerships for Health, Wealth and Innovation' has been established with multiple sub-themes (drug development, device development, business support and commercialisation, research methodology and statistics, health economics, bioethics, patient and public involvement and engagement, knowledge translation, and education and training) to support individual BRC research themes and generate cross-theme learning. The 'Partnerships' theme will support the BRC's goals by facilitating six types of partnership (with patients and citizens, clinical services, industry, across the NIHR infrastructure, across academic disciplines, and with policymakers and payers) through a range of engagement platforms and activities. We will develop a longitudinal progress narrative centred around exemplar case studies, and apply theoretical models from innovation studies (Triple Helix), sociology of science (Mode 2 knowledge production) and business studies (Value Co-creation). Data sources will be the empirical research studies within individual BRC research themes (who will apply separately for NHS ethics approval), plus documentary analysis and interviews and ethnography with research stakeholders. This study has received ethics clearance through the University of Oxford Central University Research Ethics Committee.
We anticipate that this work will add significant value to Oxford BRC. We predict accelerated knowledge translation; closer alignment of the innovation process with patient priorities and the principles of responsible, ethical research; reduction in research waste; new knowledge about the governance and activities of multi-stakeholder research partnerships and the contexts in which they operate; and capacity-building that reflects the future needs of a rapidly-evolving health research system.
生物医学研究中心（BRC）是英国医疗保健组织与大学之间的合作机构。其使命是研发新的治疗方法、技术、诊断手段及其他干预措施，以增强国家的国际竞争力，迅速将这些创新成果转化为患者的福祉，并提高医疗保健的效率、减少浪费。随着英国国家卫生研究院牛津生物医学研究中心（牛津BRC）进入其第三个五年资助期，我们力求：（1）运用证据基础，了解如何在这个大型、多利益相关方的研究系统中最佳地支持各类合作关系；（2）研究这些合作关系在一项新的、雄心勃勃的转化研究计划中如何展开。
基于行动研究原则的组织案例研究。已确立一个贯穿各领域的主题“健康、财富与创新的合作关系”，下设多个子主题（药物研发、器械研发、商业支持与商业化、研究方法与统计学、卫生经济学、生物伦理学、患者及公众参与和介入、知识转化以及教育培训），以支持牛津BRC的各个研究主题并促进跨主题学习。“合作关系”主题将通过一系列参与平台和活动，推动六种合作关系（与患者和公民、临床服务机构、产业界、英国国家卫生研究院内部各机构、各学科领域以及政策制定者和支付方）的建立，从而支持牛津BRC的目标。我们将围绕典型案例研究编写一份纵向进展报告，并应用创新研究（三螺旋模型）、科学社会学（模式2知识生产）和商业研究（价值共创）的理论模型。数据来源将包括牛津BRC各研究主题内的实证研究（这些研究将分别申请英国国民健康服务体系伦理批准），以及文献分析、与研究利益相关者的访谈和人种志研究。本研究已通过牛津大学中央大学研究伦理委员会的伦理审查。
我们预计这项工作将为牛津BRC增添重大价值。我们预测知识转化将加速；创新过程将更紧密地与患者优先事项以及负责任、符合伦理的研究原则保持一致；研究浪费将减少；将产生关于多利益相关方研究合作关系的治理和活动及其运作背景的新知识；并开展能力建设，以反映快速发展的健康研究系统的未来需求。
